Mistauren is a prescription medication used to treat certain types of cancer, including systemic mastocytosis (SM) with associated hematological neoplasm (such as acute myeloid leukemia or chronic myelomonocytic leukemia).
Composition:
Each tablet of Mistauren contains 25mg of midostaurin.
Mechanism of Action:
Midostaurin works by:
- Inhibiting the activity of certain enzymes that are involved in the growth and survival of cancer cells
- Blocking the signaling pathways that are involved in the growth and survival of cancer cells
Uses:
Mistauren is used to treat:
- Systemic mastocytosis (SM) with associated hematological neoplasm (such as acute myeloid leukemia or chronic myelomonocytic leukemia)
- Systemic mastocytosis (SM) with anemia, platelet count less than 50 x 10^9/L, or serum vitamin B12 less than 150 pg/mL
Dosage:
The recommended dosage of Mistauren is:
- 25mg taken orally twice daily, with food
Side Effects:
Common side effects of Mistauren include:
- Nausea and vomiting
- Diarrhea
- Fatigue
- Headache
- Abdominal pain
- Skin rash
- Increased risk of bleeding
- Increased risk of infections
Recommendation:
Mistauren is recommended for patients with systemic mastocytosis (SM) with associated hematological neoplasm who have not responded to other treatments. Patients should also be advised to monitor their blood counts and liver function regularly during treatment.
Important Note:
Patients should not take Mistauren if they have a history of severe allergic reactions, kidney problems, or liver problems. Patients should also inform their healthcare provider if they have any underlying medical conditions, such as heart problems or lung problems, before taking Mistauren.
Some common brands of midostaurin include:
- Rydapt (Novartis)
Please note that Mistauren is not available in all markets and may be approved for different indications and dosages in different regions.
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