AKYNZEO CAP

Akynzeo (Netupitant and Palonosetron) Capsules

Product Description: Akynzeo is a prescription medication used to prevent:

1. Chemotherapy-induced nausea and vomiting (CINV) in adult patients
2. Postoperative nausea and vomiting (PONV) in adult patients

Composition: Akynzeo consists of two active ingredients:

1. Netupitant (300mg): a substance P/neurokinin 1 (NK1) receptor antagonist that works by blocking the activity of substance P, a neurotransmitter that plays a key role in the development of nausea and vomiting.
2. Palonosetron (0.5mg): a serotonin 3 (5-HT3) receptor antagonist that works by blocking the activity of serotonin, a neurotransmitter that can contribute to nausea and vomiting.

Mechanism of Action: The combination of netupitant and palonosetron works by:

1. Blocking the activity of substance P, which reduces the release of other neurotransmitters that can contribute to nausea and vomiting
2. Blocking the activity of serotonin, which reduces the stimulation of serotonin receptors in the brain that can contribute to nausea and vomiting

Dosage: The recommended dose of Akynzeo is:

1. One capsule administered orally 30 minutes before chemotherapy or surgery
2. May be repeated every 24 hours for up to 7 days

Uses: Akynzeo is approved for the prevention of:

1. CINV in adult patients receiving chemotherapy
2. PONV in adult patients undergoing surgery

Side Effects: Common side effects of Akynzeo include:

1. Headache
2. Fatigue
3. Dizziness
4. Nausea
5. Vomiting
6. Abdominal pain
7. Constipation
8. Diarrhea

Recommendation: Akynzeo should be prescribed by a healthcare professional experienced in the management of chemotherapy-induced nausea and vomiting.

Important Note:

1. Akynzeo is not recommended for use in patients with severe kidney impairment or creatinine clearance <30 mL/min.
2. Patients with a history of allergic reactions to Akynzeo or other NK1 receptor antagonists should not receive it.
3. Women who are pregnant or breastfeeding should not receive Akynzeo.

It’s essential to discuss any concerns or questions with your healthcare provider before starting Akynzeo therapy.

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