Irinotel is a prescription medication that contains 100mg of Irinotecan, a topoisomerase I inhibitor used in the treatment of various types of cancer, including colorectal cancer, lung cancer, and breast cancer. It is available in injectable form.
Composition:
Irinotel contains 100mg of Irinotecan, a clear, colorless to yellowish solution.
Mechanism of Action:
Irinotecan works by:
- Inhibiting the activity of topoisomerase I, an enzyme that helps repair DNA damage
- Inducing DNA damage and apoptosis (cell death) in cancer cells
- Inhibiting the growth and multiplication of cancer cells
Indication:
Irinotel is indicated for:
- Treatment of metastatic colorectal cancer in combination with 5-fluorouracil (5-FU) and leucovorin
- Treatment of advanced lung cancer in combination with cisplatin
- Treatment of metastatic breast cancer in combination with docetaxel
Dosage:
The recommended dosage of Irinotel is:
- 100mg/m² intravenously every 3 weeks, repeated every 4-6 weeks
- Dose adjustments may be necessary based on patient response and toxicity
Side Effects:
Common side effects of Irinotel may include:
- Nausea and vomiting
- Diarrhea
- Fatigue
- Hair loss
- Increased risk of infections
- Hematological toxicity (anemia, neutropenia, thrombocytopenia)
- Gastrointestinal toxicity (stomatitis, esophagitis)
- Cardiac toxicity (cardiomyopathy, arrhythmias)
Recommendation:
Irinotel should only be used under the guidance of a healthcare provider. Patients receiving Irinotel treatment should be closely monitored for side effects and potential complications.
Important Note:
- Irinotel is a potent medication that can cause serious side effects, including hematological toxicity and gastrointestinal toxicity. Patients should be closely monitored for these side effects.
- Patients with a history of severe allergic reactions to irinotecan or other topoisomerase I inhibitors should not receive Irinotel.
- Patients with a history of severe kidney disease or severe liver disease should be closely monitored while receiving Irinotel.
Special Precautions:
- Patients with a history of severe neurological disorders should be closely monitored while receiving Irinotel.
- Patients with a history of bone marrow suppression or other bone marrow disorders should be closely monitored while receiving Irinotel.
It is important to note that the dosage and administration of Irinotel may vary depending on the patient’s individual needs and medical history. It is recommended that patients consult their healthcare provider before taking this medication.
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