CITAFINE 1.4MG

CITAFINE 1.4MG is a medication used to treat certain types of cancer, including breast cancer, ovarian cancer, and non-small cell lung cancer. It is an injection that works by inhibiting the activity of DNA synthesis and repair, which can help to slow down the growth of cancer cells.

Composition:

CITAFINE 1.4MG contains Gemcitabine, a medication that is a nucleoside analog.

Indications:

CITAFINE 1.4MG is indicated for the treatment of:

1. Breast cancer in combination with docetaxel
2. Ovarian cancer in combination with carboplatin
3. Non-small cell lung cancer (NSCLC) in combination with cisplatin

Mechanism of Action:

Gemcitabine works by:

1. Inhibiting the activity of DNA synthesis and repair, which can help to slow down the growth of cancer cells
2. Inhibiting the activity of enzymes that are involved in DNA synthesis and repair
3. Inducing apoptosis (cell death) in cancer cells

Dosage and Administration:

The recommended dosage of CITAFINE 1.4MG is:

• 1.4mg/m² administered as an intravenous infusion over 30 minutes every 21 days
• The dose should be adjusted based on the patient’s response to treatment and tolerability

Side Effects:

Common side effects of CITAFINE 1.4MG include:

1. Nausea and vomiting
2. Fatigue
3. Anemia
4. Leukopenia (low white blood cell count)
5. Thrombocytopenia (low platelet count)
6. Hair loss
7. Skin rash
8. Stomach pain

Serious side effects can include:

1. Hemolytic uremic syndrome (HUS) or thrombotic thrombocytopenic purpura (TTP)
2. Pulmonary toxicity (lung damage)
3. Cardiac toxicity (heart damage)

Contraindications:

CITAFINE 1.4MG is contraindicated in patients with:

1. Hypersensitivity to Gemcitabine or other nucleoside analogs
2. Severe kidney disease
3. Severe liver disease

Precautions:

1. Patients with a history of cardiac disease should be closely monitored while receiving CITAFINE 1.4MG.
2. Patients with a history of kidney disease should be closely monitored while receiving CITAFINE 1.4MG.

Patient Counseling:

• Patients should be counseled on the importance of taking their medication as directed and not missing doses.
• Patients should be instructed to report any signs of nausea or vomiting.
• Patients should be advised to report any changes in their appetite or weight loss.

Storage and Handling:

• Store at room temperature (20°C to 25°C) and protected from light.
• Do not freeze or expose to direct sunlight.
• Use within 24 months of opening.

Please note that the dosage and administration information is based on the recommended dosage and may vary depending on individual patient needs and circumstances.

As with any medication, it is important to consult with a healthcare professional before taking CITAFINE 1.4MG, especially if you have a history of medical conditions, are taking other medications, or are pregnant or breastfeeding.