Giloz 100mg

Giloz 100mg is a medication used to treat certain types of brain tumors, including glioblastoma, anaplastic astrocytoma, and recurrent medulloblastoma. It is an oral medication that works by inhibiting the growth of cancer cells and slowing down the progression of the disease.

Composition:

Giloz 100mg is a capsule containing Temozolomide, a medication that is an imidazotetrazine-based compound.

Indications:

Giloz 100mg is indicated for the treatment of:

• Glioblastoma (GBM) in combination with radiation therapy
• Anaplastic astrocytoma (AA) in combination with radiation therapy
• Recurrent medulloblastoma (MB) in patients who have progressed after conventional chemotherapy

Mechanism of Action:

Temozolomide works by:

1. Inhibiting the repair of DNA damage
2. Inducing apoptosis (cell death) in cancer cells
3. Inhibiting the growth of cancer cells

Dosage and Administration:

The recommended dosage of Giloz 100mg is:

• 100mg/m² administered orally once daily for 5 days every 4 weeks
• The dose should be adjusted based on the patient’s response to treatment and tolerability

Side Effects:

Common side effects of Giloz 100mg include:

1. Nausea and vomiting
2. Fatigue
3. Hair loss
4. Diarrhea
5. Stomatitis (mouth sores)
6. Fever
7. Hematological toxicity (low blood cell count)

Serious side effects can include:

1. Myelosuppression (low blood cell count)
2. Infections (pneumonia, sepsis)
3. Cardiac toxicity (heart failure, arrhythmias)
4. Gastrointestinal toxicity (gastrointestinal perforation)

Contraindications:

Giloz 100mg is contraindicated in patients with:

1. Severe kidney disease
2. Severe liver disease
3. Severe cardiac disease
4. Severe pulmonary disease

Precautions:

1. Patients with a history of kidney disease should be closely monitored while receiving Giloz 100mg.
2. Patients with a history of liver disease should be closely monitored while receiving Giloz 100mg.

Patient Counseling:

• Patients should be counseled on the importance of taking their medication as directed and not missing doses.
• Patients should be instructed to report any signs of nausea, vomiting, or diarrhea.
• Patients should be advised to report any changes in their appetite or weight loss.

Storage and Handling:

• Store at room temperature (20°C to 25°C) and protected from light.
• Do not freeze or expose to direct sunlight.
• Use within 24 months of opening.

Please note that the dosage and administration information is based on the recommended dosage and may vary depending on individual patient needs and circumstances.

As with any medication, it is important to consult with a healthcare professional before taking Giloz 100mg, especially if you have a history of medical conditions, are taking other medications, or are pregnant or breastfeeding.