CITAFINE 200MG INJ

Citafine 200mg is a medication used to treat various types of cancer, including breast cancer, lung cancer, ovarian cancer, and pancreatic cancer. It is an injectable medication that works by inhibiting the growth of cancer cells and slowing down the progression of the disease.

Composition:

Citafine 200mg is a solution of Gemcitabine, a medication that is a nucleoside analog.

Indications:

Citafine 200mg is indicated for the treatment of:

• Metastatic breast cancer
• Non-small cell lung cancer
• Ovarian cancer
• Pancreatic cancer
• Bladder cancer

Mechanism of Action:

Gemcitabine works by:

1. Inhibiting the enzyme ribonucleotide reductase, which is necessary for DNA synthesis
2. Interfering with the normal function of DNA, leading to cell death
3. Inducing apoptosis (cell death) in cancer cells

Dosage and Administration:

The recommended dosage of Citafine 200mg is:

• 1000mg/m² administered as a 30-minute intravenous infusion every 21 days
• The dose should be adjusted based on the patient’s response to treatment and tolerability

Side Effects:

Common side effects of Citafine 200mg include:

1. Fatigue
2. Nausea and vomiting
3. Diarrhea
4. Stomatitis (inflammation of the mouth)
5. Alopecia (hair loss)
6. Neutropenia (low white blood cell count)
7. Thrombocytopenia (low platelet count)

Serious side effects can include:

1. Myelosuppression (low blood cell count)
2. Cardiac toxicity (heart failure, arrhythmias)
3. Pulmonary toxicity (lung damage)
4. Gastrointestinal perforation (hole in the stomach or intestine)

Contraindications:

Citafine 200mg is contraindicated in patients with:

1. Severe neutropenia (low white blood cell count)
2. Severe thrombocytopenia (low platelet count)
3. Severe cardiac disease
4. Severe pulmonary disease

Precautions:

1. Patients with a history of cardiac disease should be closely monitored while receiving Citafine 200mg.
2. Patients with a history of gastrointestinal disease should be closely monitored while receiving Citafine 200mg.

Patient Counseling:

• Patients should be counseled on the importance of taking their medication as directed and not missing doses.
• Patients should be instructed to report any signs of fatigue, nausea, or diarrhea.
• Patients should be advised to report any changes in their appetite or weight loss.

Storage and Handling:

• Store at room temperature (20°C to 25°C) and protected from light.
• Do not freeze or expose to direct sunlight.
• Use within 24 months of opening.

Please note that the dosage and administration information is based on the recommended dosage and may vary depending on individual patient needs and circumstances.

As with any medication, it is important to consult with a healthcare professional before taking Citafine 200mg, especially if you have a history of medical conditions, are taking other medications, or are pregnant or breastfeeding.