Cabzored 20mg

Cabzored is a medication used to treat certain types of cancer, including medullary thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma. It is an oral tablet that works by inhibiting the activity of certain proteins that promote cancer growth and development.

Composition:

Cabzored contains Cabozantinib, a medication that is a tyrosine kinase inhibitor.

Indications:

Cabzored is indicated for the treatment of:

1. Medullary thyroid cancer (MTC) in patients with progressive disease
2. Renal cell carcinoma (RCC) in patients who have received prior anti-angiogenic therapy
3. Hepatocellular carcinoma (HCC) in patients who are unresectable or have progressed following prior systemic therapy

Mechanism of Action:

Cabozantinib works by:

1. Inhibiting the activity of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR)
2. Inhibiting the activity of c-Met, a protein involved in cell growth and proliferation
3. Inhibiting the activity of other tyrosine kinases involved in cancer cell growth and survival

Dosage and Administration:

The recommended dosage of Cabzored is:

• 20mg taken orally once daily
• The dose should be adjusted based on the patient’s response to treatment and tolerability

Side Effects:

Common side effects of Cabzored include:

1. Fatigue
2. Diarrhea
3. Nausea and vomiting
4. Decreased appetite
5. Abdominal pain
6. Dizziness
7. Headache
8. Skin rash

Serious side effects can include:

1. Hypertension (high blood pressure)
2. Increased risk of bleeding
3. Increased risk of liver injury
4. Increased risk of kidney damage
5. Severe skin reactions

Contraindications:

Cabzored is contraindicated in patients with:

1. Hypersensitivity to Cabozantinib or other tyrosine kinase inhibitors
2. Severe hepatic impairment (liver disease)
3. Severe renal impairment (kidney disease)

Precautions:

1. Patients with a history of cardiovascular disease should be closely monitored while receiving Cabzored.
2. Patients with a history of liver disease should be closely monitored while receiving Cabzored.
3. Patients with a history of kidney disease should be closely monitored while receiving Cabzored.

Patient Counseling:

• Patients should be counseled on the importance of taking their medication as directed and not missing doses.
• Patients should be instructed to report any signs of fatigue or diarrhea.
• Patients should be advised to report any changes in their appetite or weight loss.

Storage and Handling:

• Store at room temperature (20°C to 25°C) and protected from light.
• Do not freeze or expose to direct sunlight.
• Use within 30 months of opening.

Please note that the dosage and administration information is based on the recommended dosage and may vary depending on individual patient needs and circumstances.