Celzar

Celzar is a medication used to treat various types of cancer, including breast cancer, non-small cell lung cancer, and ovarian cancer. Here are some key points about the product:

Composition:

Celzar contains Gemcitabine, a nucleoside analog that is used to treat various types of cancer.

Indications:

Celzar is indicated for the treatment of:

1. Metastatic breast cancer
2. Non-small cell lung cancer
3. Ovarian cancer
4. Pancreatic cancer
5. Bladder cancer

Mechanism of Action:

Gemcitabine works by:

1. Inhibiting the production of DNA and RNA
2. Inhibiting the activity of DNA repair enzymes
3. Inducing apoptosis (cell death) in cancer cells

Dosage and Administration:

The recommended dosage of Celzar varies depending on the specific indication and patient population:

• Metastatic breast cancer: 1,000mg/m² administered as an intravenous infusion over 30 minutes every 21 days
• Non-small cell lung cancer: 1,200mg/m² administered as an intravenous infusion over 30 minutes every 21 days
• Ovarian cancer: 1,000mg/m² administered as an intravenous infusion over 30 minutes every 21 days
• Pancreatic cancer: 1,000mg/m² administered as an intravenous infusion over 30 minutes every 21 days
• Bladder cancer: 1,000mg/m² administered as an intravenous infusion over 30 minutes every 21 days

Side Effects:

Common side effects of Celzar include:

1. Nausea and vomiting
2. Fatigue
3. Anemia
4. Neutropenia (low white blood cell count)
5. Thrombocytopenia (low platelet count)
6. Headache
7. Fever

Serious side effects can include:

1. Severe allergic reactions
2. Hemolytic uremic syndrome (HUS)
3. Pulmonary toxicity
4. Cardiac toxicity

Contraindications:

Celzar is contraindicated in patients with:

1. Hypersensitivity to Gemcitabine
2. Pregnancy or breastfeeding
3. Active or suspected infections

Precautions:

1. Patients with a history of cardiac disease or cardiac dysfunction should be closely monitored while receiving Celzar.
2. Patients with a history of liver disease or liver impairment should be closely monitored while receiving Celzar.

Patient Counseling:

• Patients should be counseled on the importance of taking their medication as directed and not missing doses.
• Patients should be instructed to report any signs of nausea, vomiting, or fatigue.
• Patients should be advised to report any changes in their appetite or weight loss.

Storage and Handling:

• Store at room temperature (20°C to 25°C) and protected from moisture.
• Do not freeze or expose to direct sunlight.
• Use within 24 hours of opening.

Please note that the dosage and administration information is based on the recommended dosage and may vary depending on individual patient needs and circumstances.