Celkeran 5mg

Celkeran 5 is a medication used to treat various types of cancer, including lymphoma, leukemia, and lymphoid malignancies. It is a nitrogen mustard derivative that is used to treat cancer. Here are some key points about the product:

Composition:

Celkeran 5 contains Chlorambucil, a nitrogen mustard derivative that is used to treat cancer.

Indications:

Celkeran 5 is indicated for the treatment of:

1. Hodgkin’s lymphoma
2. Non-Hodgkin’s lymphoma (NHL)
3. Chronic lymphocytic leukemia (CLL)
4. Lymphoid malignancies
5. Cutaneous T-cell lymphoma (CTCL)

Mechanism of Action:

Chlorambucil works by:

1. Alkylating DNA and causing cell death
2. Inhibiting the repair of DNA damage
3. Interfering with the normal function of DNA and RNA

Dosage and Administration: The recommended dosage of Celkeran 5 is:

• 5mg taken orally once a day for 3-4 days, followed by a rest period of 10-14 days
• The dose may be adjusted based on the patient’s response to treatment and tolerability

Side Effects:

Common side effects of Celkeran 5 include:

1. Nausea and vomiting
2. Diarrhea
3. Fatigue
4. Low blood cell count (neutropenia, thrombocytopenia)
5. Increased risk of infections
6. Hair loss
7. Gastrointestinal toxicity

Serious side effects can include:

1. Bone marrow suppression
2. Pneumonia
3. Hemorrhagic cystitis
4. Pulmonary toxicity
5. Hepatotoxicity

Contraindications:

Celkeran 5 is contraindicated in patients with:

1. Hypersensitivity to Chlorambucil
2. Severe kidney impairment
3. Severe liver impairment
4. Pregnancy or breastfeeding

Precautions:

1. Patients with a history of cardiac disease or cardiovascular risk factors should be closely monitored while receiving Celkeran 5.
2. Patients with a history of kidney disease or liver impairment should be closely monitored while receiving Celkeran 5.
3. Patients with a history of bleeding disorders should be closely monitored while receiving Celkeran 5.

Patient Counseling:

• Patients should be counseled on the importance of taking their medication as directed and not missing doses.
• Patients should be instructed to report any signs of nausea, vomiting, or diarrhea.
• Patients should be advised to report any changes in their appetite or weight loss.

Storage and Handling:

• Store at room temperature (20°C to 25°C) and protected from moisture.
• Do not freeze or expose to direct sunlight.
• Use within 24 hours of opening.

Please note that the dosage and administration information is based on the recommended dosage and may vary depending on individual patient needs and circumstances.