Sirotem 25mg

Sirotem is a medication used to treat advanced kidney cancer (renal cell carcinoma) that has spread to other parts of the body. Here are some key points about the product:

Composition:

Sirotem contains Temsirolimus, a mTOR inhibitor that is used to treat advanced kidney cancer.

Indications:

Sirotem is indicated for the treatment of:

1. Advanced kidney cancer (renal cell carcinoma) that has spread to other parts of the body
2. Metastatic renal cell carcinoma

Mechanism of Action:

Temsirolimus works by:

1. Inhibiting the activity of an enzyme called mTOR, which is involved in the growth and proliferation of cancer cells
2. Reducing the ability of cancer cells to divide and grow
3. Inducing apoptosis (cell death) in cancer cells

Dosage and Administration:

The recommended dosage of Sirotem is:

• 25mg administered as an intravenous infusion over 30-60 minutes every week
• The dose may be adjusted based on the patient’s response to treatment and tolerability

Side Effects:

Common side effects of Sirotem include:

1. Fatigue
2. Rash
3. Diarrhea
4. Nausea and vomiting
5. Anemia
6. Low white blood cell count (neutropenia)
7. Low platelet count (thrombocytopenia)
8. High blood sugar levels

Serious side effects can include:

1. Pneumonia
2. Cardiovascular events (e.g., heart attack, stroke)
3. Respiratory events (e.g., pneumonia, pleural effusion)
4. Gastrointestinal perforation
5. Increased risk of infections

Contraindications:

Sirotem is contraindicated in patients with:

1. Hypersensitivity to Temsirolimus
2. Severe liver disease or liver impairment
3. Active or suspected infections
4. Pregnancy or breastfeeding

Precautions:

1. Patients with a history of cardiovascular disease or cardiovascular risk factors should be closely monitored while receiving Sirotem.
2. Patients with a history of liver disease or liver impairment should be closely monitored while receiving Sirotem.
3. Patients with a history of kidney disease or kidney impairment should be closely monitored while receiving Sirotem.

Patient Counseling:

• Patients should be counseled on the importance of taking their medication as directed and not missing doses.
• Patients should be instructed to report any signs of fatigue, rash, or diarrhea.
• Patients should be advised to report any changes in their appetite or weight loss.

Storage and Handling:

• Store at room temperature (20°C to 25°C) and protected from moisture.
• Do not freeze or expose to direct sunlight.
• Use within 24 hours of opening.

Please note that the dosage and administration information is based on the recommended dosage and may vary depending on individual patient needs and circumstances.