Bucelon 60mg

Bucelon is a medication used to treat various types of cancer, including leukemia and lymphoma. It is also used to prepare patients for bone marrow transplantation. Here are some key points about the product:

Composition:

Bucelon contains Busulfan, a nitrogen mustard alkylating agent that is used to treat cancer.

Indications:

Bucelon is indicated for the treatment of:

1. Acute myeloid leukemia (AML)
2. Chronic myeloid leukemia (CML)
3. Lymphoma
4. Preparation of patients for bone marrow transplantation

Mechanism of Action:

Busulfan works by:

1. Alkylating DNA and interfering with the ability of cancer cells to replicate
2. Inhibiting the repair of DNA damage
3. Inducing apoptosis (cell death) in cancer cells

Dosage and Administration:

The recommended dosage of Bucelon is:

• 60mg administered as an intravenous infusion over 30 minutes every 2 hours for 16 doses (total dose 960mg)
• The dose may be adjusted based on the patient’s response to treatment and tolerability

Side Effects:

Common side effects of Bucelon include:

1. Nausea and vomiting
2. Diarrhea
3. Fatigue
4. Hair loss
5. Skin rash
6. Low blood cell count (neutropenia, thrombocytopenia)
7. Increased risk of infections

Serious side effects can include:

1. Bone marrow suppression
2. Hemorrhagic cystitis
3. Pulmonary toxicity
4. Hepatotoxicity
5. Cardiotoxicity

Contraindications:

Bucelon is contraindicated in patients with:

1. Hypersensitivity to Busulfan
2. Severe kidney impairment
3. Severe liver impairment
4. Pregnancy or breastfeeding

Precautions:

1. Patients with a history of cardiac disease or cardiovascular risk factors should be closely monitored while receiving Bucelon.
2. Patients with a history of kidney disease or liver impairment should be closely monitored while receiving Bucelon.
3. Patients with a history of bleeding disorders should be closely monitored while receiving Bucelon.

Patient Counseling:

• Patients should be counseled on the importance of taking their medication as directed and not missing doses.
• Patients should be instructed to report any signs of nausea, vomiting, or diarrhea.
• Patients should be advised to report any changes in their appetite or weight loss.

Storage and Handling:

• Store at room temperature (20°C to 25°C) and protected from moisture.
• Do not freeze or expose to direct sunlight.
• Use within 24 hours of opening.

Please note that the dosage and administration information is based on the recommended dosage and may vary depending on individual patient needs and circumstances.