Estramin

Estramin is a prescription medication used to treat advanced breast cancer, particularly in patients with estrogen-receptor positive tumors. It is a hormonal therapy that works by blocking the production of estrogen in the body, which can help slow down the growth of cancer cells.

Composition:

• Estramin: Estramustine 140mg Capsule

Mechanism of Action:

Estramustine, the active ingredient in Estramin, works by:

1. Inhibiting the activity of the enzyme 17 beta-hydroxysteroid dehydrogenase, which is involved in the conversion of testosterone to estrogen.
2. Blocking the production of estrogen in the body, which can help slow down the growth of cancer cells.

Indications:

Estramin is approved for the treatment of:

• Advanced breast cancer in patients who have not responded to other treatments.
• Hormone-receptor positive breast cancer in patients who have not responded to other treatments.

Dosage:

The recommended dosage of Estramin is:

• 140mg orally, three times a day, for a maximum of 28 days.
• The recommended duration of treatment is until disease progression or unacceptable toxicity.

Side Effects:

Common side effects of Estramin include:

1. Nausea and vomiting
2. Diarrhea
3. Fatigue
4. Headache
5. Dizziness
6. Increased risk of bleeding
7. Increased risk of infections
8. Increased risk of liver damage
9. Hot flashes
10. Changes in menstrual cycle

Recommendation:

Estramin is recommended for patients with advanced breast cancer who have not responded to other treatments.

Important Note:

• Patients taking Estramin should be closely monitored for signs of liver damage or kidney damage.
• Patients taking Estramin should avoid taking medications that may interact with it, such as anticoagulants or medications that can increase the risk of bleeding.
• Pregnant or breastfeeding women should not use Estramin, as it may harm the fetus or infant.
• Regular follow-up appointments with your healthcare provider are necessary to monitor the effectiveness of Estramin and to detect any potential side effects or complications.

Special Precautions:

• Patients with a history of liver disease or kidney disease should be closely monitored while taking Estramin.
• Patients taking Estramin should avoid taking medications that may increase the risk of liver damage or kidney damage.
• Patients with a history of bleeding disorders or platelet disorders should be closely monitored while taking Estramin.

Contraindications:

• Patients with severe liver disease or severe kidney disease should not use Estramin.
• Patients who are pregnant or breastfeeding should not use Estramin.
• Patients who are allergic to estramustine or any other component of Estramin should not use it.