Nexavar 200MG

Nexavar is a brand name for Sorafenib 200mg, which is a medication used to treat certain types of cancer. Here are some key points about the product:

Composition:

Sorafenib 200mg is a tablet containing sorafenib, a multikinase inhibitor that targets various kinases involved in cancer cell proliferation and survival.

Indications:

Sorafenib 200mg is indicated for the treatment of:

1. Unresectable hepatocellular carcinoma (HCC) in patients with advanced disease
2. Advanced renal cell carcinoma (RCC) in patients with poor or intermediate risk of metastasis
3. Thyroid cancer (differentiated and undifferentiated)

Mechanism of Action:

Sorafenib 200mg works by:

1. Inhibiting the activity of various kinases, including VEGFR-2, PDGFR-β, and Raf-1, which are involved in cancer cell proliferation and survival
2. Reducing the production of vascular endothelial growth factor (VEGF), a protein that promotes angiogenesis and tumor growth

Dosage and Administration:

The recommended dosage of Sorafenib 200mg is:

• 400mg (2 x 200mg tablets) taken orally twice daily, with or without food
• Take at the same time each day

Side Effects:

Common side effects of Sorafenib 200mg include:

1. Fatigue
2. Dermatological toxicity (e.g., rash, skin lesions)
3. Diarrhea
4. Nausea
5. Abdominal pain
6. Palpitations
7. Hematological toxicity (e.g., anemia, thrombocytopenia)

Serious side effects can include:

1. Hepatotoxicity (e.g., liver damage)
2. Cardiovascular toxicity (e.g., hypertension, arrhythmias)
3. Gastrointestinal perforation
4. Pulmonary arterial hypertension

Contraindications:

Sorafenib 200mg is contraindicated in patients with:

1. Hypersensitivity to sorafenib
2. Pregnant or breastfeeding women
3. Severe hepatic impairment (Child-Pugh C)

Precautions:

1. Patients with a history of cardiac disease or cardiac dysfunction should be closely monitored while receiving Sorafenib 200mg.
2. Patients with a history of liver disease or liver damage should be closely monitored while receiving Sorafenib 200mg.

Patient Counseling:

• Patients should be counseled on the importance of taking their medication as directed and not missing doses.
• Patients should be instructed to report any signs of skin lesions or rash.
• Patients should be advised to report any changes in their appetite, nausea, or vomiting.

Storage and Handling:

• Store bottles at room temperature between 15°C and 30°C (59°F and 86°F).
• Do not expose to direct sunlight or moisture.
• Use within 24 hours of opening.

Please note that the dosage and administration information is based on the recommended dosage and may vary depending on individual patient needs and circumstances.