Peg-Frastim is a prescription medication used to prevent bleeding in patients with bleeding disorders, such as hemophilia A or hemophilia B. It is a recombinant glycoprotein IX, which is used to replace the missing clotting factor in these patients.
Composition:
- Peg-Frastim: Pegylated 6mg/0.6ml Injection
Mechanism of Action:
Peg-Frastim works by:
- Replacing the missing clotting factor IX in patients with hemophilia A or hemophilia B.
- Helping to prevent bleeding by activating the clotting cascade and promoting blood clot formation.
Indications:
Peg-Frastim is approved for the prevention of bleeding in patients with:
- Hemophilia A (classic hemophilia)
- Hemophilia B (Christmas disease)
- Congenital factor IX deficiency
Dosage:
The recommended dosage of Peg-Frastim is:
- 1-2mg/kg every 7-14 days, depending on the patient’s individual response and severity of bleeding.
- The recommended duration of treatment is until the patient’s bleeding disorder is controlled or until unacceptable toxicity occurs.
Side Effects:
Common side effects of Peg-Frastim include:
- Infusion reactions
- Headache
- Fatigue
- Muscle pain
- Nausea
- Vomiting
- Allergic reactions
- Increased risk of bleeding
Recommendation:
Peg-Frastim is recommended for patients with hemophilia A or hemophilia B who have not responded to other treatments.
Important Note:
- Patients taking Peg-Frastim should be closely monitored for signs of bleeding or allergic reactions.
- Patients taking Peg-Frastim should avoid taking medications that may interact with it, such as anticoagulants or medications that can increase the risk of bleeding.
- Pregnant or breastfeeding women should not use Peg-Frastim, as it may harm the fetus or infant.
- Regular follow-up appointments with your healthcare provider are necessary to monitor the effectiveness of Peg-Frastim and to detect any potential side effects or complications.
Special Precautions:
- Patients with a history of allergic reactions to recombinant glycoprotein IX or any other component of Peg-Frastim should not use it.
- Patients with a history of severe liver disease or kidney disease should be closely monitored while taking Peg-Frastim.
Contraindications:
- Patients who are allergic to pegylated glycoprotein IX or any other component of Peg-Frastim should not use it.
- Patients who are pregnant or breastfeeding should not use Peg-Frastim.
- Patients with severe liver disease or severe kidney disease should not use Peg-Frastim.
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