Estram

Estram is a brand name for Estramustine 140mg Capsules, which is a medication used to treat certain types of cancer. Here are some key points about the product:

Composition:

Each 140mg capsule of Estram contains 140mg of Estramustine, a semisynthetic estrogen with antitumor properties.

Indications:

Estram is indicated for the treatment of:

1. Prostate cancer (metastatic)
2. Hormone-refractory prostate cancer

Mechanism of Action:

Estramustine works by:

1. Inhibiting the growth and proliferation of cancer cells
2. Reducing the production of testosterone and other androgens that promote tumor growth
3. Interfering with the uptake of estradiol by cancer cells

Dosage and Administration:

The recommended dosage of Estram is:

• 140mg taken orally once daily, with or without food
• The dosage may be adjusted depending on the patient’s response to treatment

Side Effects:

Common side effects of Estram include:

1. Gastrointestinal disturbances (e.g., nausea, vomiting, diarrhea)
2. Fatigue
3. Headache
4. Muscle pain
5. Nausea
6. Abdominal pain
7. Flu-like symptoms

Serious side effects can include:

1. Cardiac problems (e.g., arrhythmias, congestive heart failure)
2. Liver dysfunction
3. Hemolytic anemia or thrombocytopenia
4. Gastrointestinal bleeding or perforation

Contraindications:

Estram is contraindicated in patients with:

1. Known hypersensitivity to estramustine
2. Pregnancy or breastfeeding (unless absolutely necessary)
3. History of cardiac disease or cardiac dysfunction
4. Severe liver disease

Precautions:

1. Patients with a history of cardiac disease or cardiac dysfunction should be closely monitored while receiving Estram.
2. Patients with a history of liver disease or kidney dysfunction should receive dose reduction or close monitoring while receiving Estram.
3. Patients with a history of blood disorders should be closely monitored for signs of blood dyscrasias.

Patient Counseling:

• Patients should be counseled on the importance of taking their medication as directed and not missing doses.
• Patients should be instructed to report any signs of infection, such as fever, chills, or sore throat.
• Patients should be advised to report any changes in their appetite, nausea, or vomiting.
• Patients should be informed that they may experience bleeding or bruising during treatment.

Storage and Handling:

• Store capsules at room temperature between 15°C and 30°C (59°F and 86°F).
• Do not expose to direct sunlight or moisture.
• Use within 28 days of opening.

Please note that the dosage and administration information is based on the recommended dosage and may vary depending on individual patient needs and circumstances.