Persol Plus gel

### Persol Plus (Adapalene + Benzoyl Peroxide Gel) **PRODUCT DESCRIPTION:** Persol Plus is a topical gel that combines two active ingredients, adapalene and benzoyl peroxide, to treat acne. This combination provides a well-rounded approach to acne management, targeting multiple aspects of acne pathophysiology. **COMPOSITION:** – **Adapalene**: Typically 0.1% or 0.3%. A topical retinoid that modulates skin cell growth and differentiation, and helps prevent clogged pores. – **Benzoyl Peroxide**: Usually 2.5% to 10%. An antibacterial agent that reduces the number of bacteria on the skin and has a keratolytic (exfoliating) effect, helping to clear existing acne lesions and prevent new ones. **MECHANISM OF ACTION:** 1. **Adapalene**: – Reduces keratinocyte proliferation and promotes skin cell turnover. – Decreases the formation of microcomedomes (the precursor to acne lesions). – Has anti-inflammatory properties that help decrease redness and swelling. 2. **Benzoyl Peroxide**: – Kills *Propionibacterium acnes*, the bacteria involved in the development of acne. – Acts as a mild exfoliant, helping to clear pores and reduce the formation of new acne lesions. – Reduces inflammation and redness associated with acne. **INDICATIONS:** Persol Plus is indicated for the treatment of: – Mild to moderate acne vulgaris, especially inflammatory acne lesions such as papules and pustules. **DIRECTIONS FOR USE:** 1. **Cleanse the Skin**: Gently wash the affected area with a mild cleanser and pat dry. 2. **Application**: – Apply a thin layer of Persol Plus Gel to the affected areas once daily, preferably at night. – Use only the amount recommended by a healthcare provider to prevent excessive dryness or irritation. 3. **Avoid Sensitive Areas**: Avoid contact with the eyes, mouth, and open wounds. 4. **Wash Hands**: Wash hands thoroughly after application. **SIDE EFFECTS:** Common side effects may include: – Skin irritation (redness, burning, peeling) – Dryness or flaking of the skin – Allergic reactions (although rare, may occur; signs include rash or swelling) **IMPORTANT NOTE:** – This gel is for topical use only and should not be ingested. – Patients should avoid using other acne medications or products that may cause further irritation unless directed by a healthcare provider. – Sun protection is important, as the skin may become more sensitive to sunlight. A non-comedogenic sunscreen is recommended. **RECOMMENDATIONS:** – Follow the prescribed application routine for the best results. – If irritation occurs, it may be helpful to reduce the frequency of application or consult a healthcare professional. – Results may take several weeks to become noticeable; patience is essential. As always, consult with a healthcare professional or dermatologist for personalized advice, especially for ongoing skin concerns or if you experience significant discomfort while using this medication.