REVAC-B PLUS is a recombinant DNA hepatitis B vaccine used for active immunization against hepatitis B virus (HBV) infection in adults. It contains purified hepatitis B surface antigen (HBsAg) to stimulate protective immunity.
Composition
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Active Ingredient:
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Hepatitis B Surface Antigen (HBsAg) – 20 mcg/mL (adsorbed on aluminum hydroxide).
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Adjuvant:
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Aluminum hydroxide gel (enhances immune response).
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Preservative:
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Thiomersal (in some formulations) – Check label for preservative-free versions.
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Mechanism of Action
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Stimulates antibody production (anti-HBs)Â against HBV.
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Provides long-term immunity (prevents chronic hepatitis B, cirrhosis, and liver cancer).
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Requires multiple doses for full protection.
Dosage & Schedule
Standard Adult Immunization (3-Dose Schedule):
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First dose: Day 0.
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Second dose: 1 month after first dose.
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Third dose: 6 months after first dose.
Accelerated Schedule (for high-risk adults):
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0, 1, and 2 months, with a booster at 12 months.
Administration:
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Intramuscular (IM) injection in the deltoid muscle.
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Do not inject intravenously or subcutaneously.
Uses
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Primary prevention of hepatitis BÂ in unvaccinated adults.
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High-risk groups:
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Healthcare workers.
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Chronic liver disease patients.
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Sexually active individuals with multiple partners.
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IV drug users.
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Post-exposure prophylaxis (with hepatitis B immunoglobulin if needed).
Storage
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Store at 2–8°C (refrigerated) – Do not freeze.
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Protect from light.
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Discard if cloudy or contains particles.
Recommendations
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Check antibody titers (anti-HBs)Â post-vaccination in high-risk individuals.
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Booster doses may be needed if anti-HBs levels drop below 10 mIU/mL.
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Safe for pregnant & breastfeeding women (non-infectious recombinant vaccine).
Important Notes
Side Effects
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Common: Pain/swelling at injection site, mild fever, fatigue.
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Rare: Allergic reactions (hives, anaphylaxis).
Contraindications
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Hypersensitivity to yeast or vaccine components.
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Severe febrile illness (delay vaccination until recovery).
Efficacy
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>95% effective in healthy adults when the full schedule is completed.
Complete the vaccination series for optimal protection.
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