SOVIHEP-V is a fixed-dose combination antiviral medication containing Sofosbuvir (400 mg) + Velpatasvir (100 mg). It is used to treat chronic hepatitis C virus (HCV) infection in adults, offering a high cure rate across multiple HCV genotypes.
Composition
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Active Ingredients:
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Sofosbuvir (400 mg) – HCV NS5B polymerase inhibitor.
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Velpatasvir (100 mg) – HCV NS5A replication complex inhibitor.
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Inactive Ingredients:
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Microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide.
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Mechanism of Action
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Sofosbuvir: Blocks HCV RNA replication by inhibiting the NS5B polymerase.
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Velpatasvir: Prevents viral assembly by targeting the NS5A protein.
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Combined effect: Highly effective in suppressing HCV replication, leading to sustained virologic response (SVR).
Dosage & Administration
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Standard Dose: 1 tablet (400/100 mg) once daily, taken with or without food.
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Treatment Duration:
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12 weeks for most genotypes (1-6).
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24 weeks for cirrhotic patients with genotype 3.
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Missed Dose: Take as soon as remembered, but skip if close to the next dose.
Uses
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Chronic HCV Infection (Genotypes 1-6).
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Compensated Cirrhosis (with or without HIV co-infection).
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Post-Liver Transplant HCV Recurrence.
Storage
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Store below 30°C in a dry place.
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Keep in original packaging (protects from moisture).
Recommendations
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Take consistently at the same time daily.
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Avoid proton pump inhibitors (PPIs) – Take 4 hours apart if needed.
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Monitor liver function tests (LFTs)Â during treatment.
Important Notes
Side Effects
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Common: Fatigue, headache, nausea.
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Rare: Bradycardia (if taken with amiodarone), anemia.
Contraindications
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Concurrent use with rifampin or St. John’s wort (reduces efficacy).
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Severe liver impairment (Child-Pugh C) – Use with caution.
Drug Interactions
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Antacids/PPIs: Reduce velpatasvir absorption.
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Amiodarone: Risk of severe bradycardia.
Achieves >95% cure rate in most patients.
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