Axentri

Axentri is a medication that contains Maraviroc, which is an antiretroviral drug used in the treatment of HIV (Human Immunodeficiency Virus) infection. Below is a detailed overview of Axentri, including its uses, mechanism of action, dosage, side effects, and recommendations.

Composition

• Active Ingredient: Maraviroc
• Strength: Typically available in 150 mg tablet form.

Uses

• HIV Treatment: Axentri is indicated for the treatment of HIV-1 infection in adults and children (weighing at least 40 kg) in combination with other antiretroviral medications. It is specifically used for patients who have CCR5-tropic HIV-1, meaning the virus primarily uses the CCR5 co-receptor to enter cells.

Mechanism of Action

• CCR5 Antagonist: Maraviroc works by blocking the CCR5 co-receptor on the surface of CD4 cells, which HIV uses to enter and infect these cells. By preventing the virus from binding to the CCR5 co-receptor, Maraviroc inhibits HIV entry into the cells, thus preventing the infection from progressing.

Dosage

• Adults: The usual recommended dosage is 300 mg taken orally twice daily for patients who are taking other antiretroviral drugs.
• Children: For pediatric patients, the dosage is based on weight and should be determined by a healthcare provider.

Side Effects

Common side effects may include:

• Gastrointestinal Issues: Nausea, diarrhea, and abdominal discomfort.
• Fatigue: General feelings of tiredness.
• Headache: A common complaint among users.
• Dizziness: Some patients may experience dizziness or lightheadedness.

Serious Side Effects (Seek Medical Attention Immediately)

• Severe Allergic Reactions: Symptoms may include difficulty breathing, swelling of the face, lips, or throat.
• Hepatotoxicity: Symptoms include jaundice (yellowing of the skin or eyes), dark urine, pale stools, and severe abdominal pain.
• Increased Risk of Infections: Due to potential immune suppression, patients may experience increased susceptibility to infections.
• Cardiovascular Issues: Maraviroc has been associated with orthostatic hypotension (drop in blood pressure when standing), though this is less common.

Recommendations

1. Adherence: It is crucial to take Axentri exactly as prescribed to maintain effective viral suppression and minimize the risk of drug resistance.
2. Regular Monitoring: Schedule regular follow-ups with your healthcare provider to monitor liver function, viral load, and overall health.
3. Management of Side Effects: Report any unusual or severe side effects to your healthcare provider right away.
4. Healthy Lifestyle: Maintain a balanced diet and engage in regular physical activity to support your immune system and overall health.
5. Inform About Other Medications: Always inform your healthcare provider about any other medications, supplements, or herbal products you are taking to avoid potential interactions.

Important Notes

• Tropism Testing Required: Before initiating Maraviroc, it is essential to perform tropism testing to confirm the presence of CCR5-tropic HIV-1, as Maraviroc is ineffective against HIV that uses the CXCR4 co-receptor.
• Axentri is typically used in combination with other antiretroviral agents and should not be used as a stand-alone treatment for HIV.

If you have any specific questions or need further information about Axentri (Maraviroc), feel free to ask!