Daruvir is a tablet that contains Darunavir (800mg), a protease inhibitor used to treat human immunodeficiency virus (HIV) infection in adults.
Composition:
- Darunavir: 800mg
- Tablet core: lactose monohydrate, magnesium stearate, silicon dioxide
- Film coating: hypromellose, polyethylene glycol, titanium dioxide
Mechanism of Action:
Daruvir works by inhibiting the activity of HIV protease, an enzyme necessary for the virus to replicate. Darunavir is a substrate-based inhibitor that binds to the active site of HIV protease, preventing it from cleaving the viral polyprotein and inhibiting the production of new viral particles.
Uses:
Daruvir is used to treat HIV infection in adults. It is recommended for patients who have not previously received antiretroviral therapy or who have failed other antiretroviral regimens.
Dosage:
The recommended dosage of Daruvir is one tablet once daily, taken with food.
Side Effects:
Common side effects of Daruvir include:
- Headache
- Nausea
- Vomiting
- Diarrhea
- Fatigue
- Dizziness
- Insomnia
- Rash
- Abnormal dreams
- Increased blood lipids
- Neuropathy (nerve damage)
- Lactic acidosis (build-up of lactic acid in the blood)
Recommendation:
Daruvir should be used under the guidance of a healthcare professional. Patients should be monitored regularly for liver function tests, lipid profiles, and glucose levels.
Important Note:
- Daruvir is not recommended for use in patients with severe liver disease (Child-Pugh C).
- Patients with pre-existing kidney disease should be monitored closely for signs of kidney damage or toxicity.
- Patients taking other medications, including antiretroviral agents, may be at risk for interactions with Daruvir.
- The safety and efficacy of Daruvir in pregnant or lactating women have not been established.
- Patients should be counseled on the importance of taking concomitant therapy as prescribed by their healthcare provider.
- Patients should be monitored for neuropsychiatric symptoms, such as depression, anxiety, and sleep disorders.
Special Precautions:
- Daruvir should be taken with food to improve absorption.
- Patients with diabetes should be monitored closely for changes in blood glucose levels.
- Patients with pre-existing kidney disease should be monitored closely for signs of kidney damage or toxicity.
- Patients with liver disease should be monitored closely for signs of liver damage or toxicity.
- Patients taking other medications that may interact with Daruvir should be monitored closely for signs of toxicity or adverse effects.
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