Daruvir 300mg

Daruvir is an antiretroviral medication containing darunavir, which is used in the treatment of HIV-1 infection. Darunavir is a protease inhibitor and is part of antiretroviral therapy (ART) regimen, usually in combination with other HIV medications, along with a boosting agent like ritonavir or cobicistat to enhance its effectiveness.

Composition:

Each Daruvir tablet contains:

• Darunavir: 300 mg

Uses:

Daruvir is used for:

• The treatment of HIV-1 infection in combination with other antiretroviral medications.
• It helps to control HIV infection, increase CD4 (T) cell counts, and reduce the amount of HIV in the blood (viral load).

Mechanism of Action:

• Darunavir: Inhibits the HIV-1 protease enzyme. Protease is necessary for the proteolytic cleavage of the viral polyprotein precursors into individual functional proteins required for the production of infectious viral particles. By inhibiting this enzyme, darunavir prevents the maturity and replication of the virus, leading to the production of immature, non-infectious viral particles.

Dosage:

• Adults: The typical dosage is 800 mg of darunavir (which could be two 400 mg tablets or other equivalent dosages) once daily, boosted with 100 mg of ritonavir or 150 mg of cobicistat, taken with food. Alternatively, 600 mg of darunavir taken twice daily with 100 mg of ritonavir twice daily can be prescribed for treatment-experienced patients.
• Children and Adolescents: Dosage is based on body weight and should be determined by a healthcare provider. Pediatric patients should follow the specific dosage regimen provided by their healthcare provider.

Side Effects:

Common side effects:

• Diarrhea
• Nausea
• Headache
• Abdominal pain
• Rash
• Vomiting

Serious side effects (less common):

• Liver problems (symptoms include yellowing of the skin or eyes, dark urine)
• Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis)
• Allergic reactions (symptoms include difficulty breathing, swelling of the face and throat)
• Increased blood sugar levels (hyperglycemia)
• Changes in body fat distribution

Recommendations:

• Take Daruvir exactly as prescribed by your healthcare provider.
• Darunavir should always be taken with food to improve absorption and effectiveness.
• Always take darunavir with a boosting agent like ritonavir or cobicistat as directed by your healthcare provider.
• Do not miss doses or adjust the dose on your own.
• Inform your healthcare provider about all other medications and supplements you are taking to avoid potential drug interactions.

Important Note:

• Regularly monitor liver function, as darunavir can cause liver problems. Patients with preexisting liver conditions should use darunavir with caution.
• Maintain regular follow-ups with your healthcare provider to monitor the effectiveness and side effects of the treatment.
• Pregnant women or those planning to become pregnant should inform their healthcare provider to discuss the potential risks and benefits.
• Store the medication at room temperature, away from moisture and direct light.
• Do not stop taking Daruvir without consulting your healthcare provider, as this may increase viral load and lead to resistance.
• Report any new symptoms or side effects to your healthcare provider immediately.

This detailed overview covers the essential aspects of Daruvir (Darunavir 300 mg Tablet). Always consult your healthcare provider for personalized medical advice and treatment adjustments.