Daruvir 600mg

Daruvir is a tablet that contains Darunavir (600mg), a protease inhibitor used to treat human immunodeficiency virus (HIV) infection in adults.

Composition:

• Darunavir: 600mg
• Tablet core: lactose monohydrate, magnesium stearate, silicon dioxide
• Film coating: hypromellose, polyethylene glycol, titanium dioxide

Mechanism of Action:

Daruvir works by inhibiting the activity of HIV protease, an enzyme necessary for the virus to replicate. Darunavir is a substrate-based inhibitor that binds to the active site of HIV protease, preventing it from cleaving the viral polyprotein and inhibiting the production of new viral particles.

Uses:

Daruvir is used to treat HIV infection in adults. It is recommended for patients who have not previously received antiretroviral therapy or who have failed other antiretroviral regimens.

Dosage:

The recommended dosage of Daruvir is one tablet once daily, taken with food.

Side Effects:

Common side effects of Daruvir include:

• Headache
• Nausea
• Vomiting
• Diarrhea
• Fatigue
• Dizziness
• Insomnia
• Rash
• Abnormal dreams
• Increased blood lipids
• Neuropathy (nerve damage)
• Lactic acidosis (build-up of lactic acid in the blood)

Recommendation:

Daruvir should be used under the guidance of a healthcare professional. Patients should be monitored regularly for liver function tests, lipid profiles, and glucose levels.

Important Note:

• Daruvir is not recommended for use in patients with severe liver disease (Child-Pugh C).
• Patients with pre-existing kidney disease should be monitored closely for signs of kidney damage or toxicity.
• Patients taking other medications, including antiretroviral agents, may be at risk for interactions with Daruvir.
• The safety and efficacy of Daruvir in pregnant or lactating women have not been established.
• Patients should be counseled on the importance of taking concomitant therapy as prescribed by their healthcare provider.
• Patients should be monitored for neuropsychiatric symptoms, such as depression, anxiety, and sleep disorders.

Special Precautions:

• Daruvir should be taken with food to improve absorption.
• Patients with diabetes should be monitored closely for changes in blood glucose levels.
• Patients with pre-existing kidney disease should be monitored closely for signs of kidney damage or toxicity.
• Patients with liver disease should be monitored closely for signs of liver damage or toxicity.
• Patients taking other medications that may interact with Daruvir should be monitored closely for signs of toxicity or adverse effects.

Clinical Trials:

Daruvir has been studied in clinical trials in combination with other antiretroviral agents. The results of these trials have shown that Daruvir is effective in suppressing HIV replication and improving patient outcomes.

Contraindications:

Daruvir is contraindicated in patients who are allergic to darunavir or any of its ingredients. It is also contraindicated in patients with severe liver disease (Child-Pugh C).