Dinex EC 250mg

Dinex EC contains didanosine, which is an antiretroviral medication belonging to the class of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs). Didanosine is used in combination with other antiretroviral agents for the treatment and management of HIV-1 infection. The “EC” stands for enteric-coated, which means the capsule is designed to dissolve in the small intestine rather than the stomach to reduce gastrointestinal side effects.

Composition:

Each Dinex EC capsule contains:

• Didanosine (ddI): 250 mg

Uses:

Dinex EC is used for:

• The treatment of HIV-1 infection in combination with other antiretroviral medications.
• It helps reduce the viral load in the blood (amount of HIV) and increases CD4 (T) cell counts, which are essential for a healthy immune system.

Mechanism of Action:

• Didanosine: Inhibits the HIV reverse transcriptase enzyme, which is crucial for the conversion of viral RNA into DNA. By blocking this enzyme, didanosine prevents the replication of HIV within the host cells, thereby reducing viral load.

Dosage:

• Adults: The typical dosage is based on body weight. For adults weighing at least 60 kg, the usual dose is 400 mg once daily. For those weighing less than 60 kg, the dose is typically 250 mg once daily.
• Children: The dosage varies based on body weight and age, and should be determined by a healthcare provider.

Note: Didanosine should be taken on an empty stomach, ideally 30 minutes before or 2 hours after a meal.

Side Effects:

Common side effects:

• Nausea
• Diarrhea
• Headache
• Abdominal pain
• Rash

Less common but serious side effects:

• Pancreatitis (inflammation of the pancreas)
• Peripheral neuropathy (nerve damage causing pain, tingling, or numbness in hands and feet)
• Lactic acidosis (buildup of lactic acid in the blood)
• Hepatomegaly with steatosis (enlarged liver with fat accumulation)
• Retinal changes and optic neuritis (changes in the back of the eye and inflammation of the optic nerve)

Recommendations:

• Take Dinex EC exactly as prescribed by your healthcare provider.
• Do not adjust your dose or stop taking the medication without consulting your healthcare provider.
• Take the medication on an empty stomach for optimal absorption.
• Inform your healthcare provider about all other medications and supplements you are taking to avoid potential drug interactions.

Important Note:

• Pancreatitis: Be aware of the symptoms of pancreatitis (such as severe abdominal pain, back pain, nausea, vomiting). If these symptoms occur, seek medical attention immediately and discontinue the medication.
• Peripheral Neuropathy: Monitor for symptoms of nerve damage, such as pain, tingling, or numbness in the hands or feet.
• Regularly monitor liver function and blood counts as part of ongoing treatment with didanosine.
• Pregnant women or those planning to become pregnant should inform their healthcare provider to discuss the potential risks and benefits.
• Store the medication at room temperature, away from moisture and direct light.
• Keep all medical appointments and undertake regular blood tests to monitor your overall health and the efficacy of the treatment.
• Report any new symptoms or side effects to your healthcare provider immediately.

This overview covers the essential aspects of Dinex EC (Didanosine 250 mg Capsule). For any specific concerns or questions, always consult your healthcare provider.