Indivan 400 mg

Indivan contains indinavir, which is an antiretroviral medication used to manage and treat HIV-1 infection. Indinavir belongs to the class of drugs known as protease inhibitors. It is usually prescribed in combination with other antiretroviral medications to control HIV infection and improve immune function.

Composition:

Each Indivan capsule contains:

• Indinavir: 400 mg

Uses:

Indivan is used for:

• The treatment of HIV-1 infection in combination with other antiretroviral agents.
• It helps reduce the viral load in the blood (amount of HIV) and increases CD4 (T) cell counts, which are essential for a healthy immune system.

Mechanism of Action:

• Indinavir: Inhibits the HIV-1 protease enzyme, which is essential for the proteolytic cleavage of viral polyprotein precursors into functional proteins required for viral replication. By blocking this enzyme, indinavir prevents the maturation of the virus, leading to the production of immature, non-infectious viral particles, thereby reducing viral load.

Dosage:

• Adults: The usual dose for adults is 800 mg every 8 hours. Indinavir must be taken exactly as prescribed to maintain effective drug levels in the blood.
• Children: The dosage for pediatric patients varies based on body weight and should be determined by a healthcare provider.

Note: Indinavir should be taken on an empty stomach (1 hour before or 2 hours after a meal) to improve absorption, or with a light meal that is low in fat and protein. Adequate hydration is also important to reduce the risk of kidney stones.

Side Effects:

Common side effects:

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache
• Fatigue
• Metallic taste or altered taste

Less common but serious side effects:

• Nephrolithiasis (kidney stones)
• Hematuria (blood in the urine)
• Hyperbilirubinemia (elevated bilirubin, which may cause jaundice)
• Hepatotoxicity (liver damage)
• Lipodystrophy (changes in body fat distribution)
• Hyperglycemia (high blood sugar levels)

Recommendations:

• Take Indivan exactly as prescribed by your healthcare provider.
• Maintain consistent dosing schedules to ensure effective drug levels in the blood.
• Take the medication with plenty of water to prevent kidney stones (recommended at least 1.5 liters of water daily).
• Inform your healthcare provider about all other medications and supplements you are taking to avoid potential drug interactions.
• Avoid high-fat meals when taking indinavir as they can reduce the drug’s effectiveness.

Important Note:

• Hydration: Ensure adequate fluid intake to reduce the risk of kidney stones. Drink plenty of fluids throughout the day, especially around the time of dosing.
• Liver Function: Regular monitoring of liver function tests is recommended to detect any potential liver-related side effects.
• Pregnant women or those planning to become pregnant should inform their healthcare provider to discuss potential risks and benefits.
• Store the medication at room temperature, away from moisture and direct light.
• Keep all medical appointments and undergo regular blood tests to monitor your overall health and the efficacy of the treatment.
• Report any new symptoms or side effects to your healthcare provider immediately, especially signs of kidney stones or liver problems.

This overview covers the essential aspects of Indivan (Indinavir 400 mg Capsules). Always consult your healthcare provider for personalized medical advice and treatment adjustments.