Isentress

Isentress is a brand name for the medication Raltegravir, which is an antiretroviral drug used in the treatment of HIV (Human Immunodeficiency Virus) infection. Here’s a detailed overview of Isentress, including its uses, mechanism of action, dosage, side effects, and recommendations:

Composition

• Active Ingredient: Raltegravir
• Strength: Typically available in 400 mg tablets.

Uses

• HIV Treatment: Isentress is indicated for the treatment of HIV-1 infection in adults and children aged 2 years and older. It is often used as part of a combination antiretroviral therapy (ART) regimen to decrease viral load and improve overall immune function.

Mechanism of Action

• Integrase Inhibitor: Raltegravir works by inhibiting the HIV integrase enzyme, which is responsible for integrating the viral DNA into the host cell’s DNA. By blocking this enzyme, Raltegravir prevents the replication of HIV and helps control the virus in the body.

Dosage

• Adults: The standard recommended dose of Isentress is 400 mg taken orally twice daily or 800 mg once daily. However, the precise dosage may vary based on individual factors, such as the presence of other medications or specific health conditions.
• Pediatric Patients: For children aged 2 to less than 12 years, the dosage may be based on weight and should be determined by a healthcare provider.

Side Effects

Common side effects may include:

• Gastrointestinal Issues: Nausea, diarrhea, vomiting, or abdominal pain.
• Fatigue: General feelings of tiredness.
• Headache: A common complaint among users.
• Skin Rash: Can occur, though severe rashes are less common.
• Elevated Liver Enzymes: May indicate liver irritation or damage.

Serious Side Effects (Seek Medical Attention Immediately)

• Severe Allergic Reactions: Such as difficulty breathing or swelling of the face, lips, or throat.
• Severe Skin Reactions: Such as Stevens-Johnson syndrome or toxic epidermal necrolysis (though rare).
• Liver Problems: Symptoms may include jaundice (yellowing of the skin or eyes), dark urine, or persistent abdominal pain.

Recommendations

1. Adherence: It is crucial to take Isentress exactly as prescribed to maintain effective viral suppression and reduce the risk of drug resistance. Consistency in timing (whether twice daily or once daily) is important.
2. Regular Monitoring: Schedule regular visits with your healthcare provider to monitor your health, track viral load, and check liver function through blood tests.
3. Management of Side Effects: Inform your healthcare provider of any side effects you experience, especially if they are severe or persistent.
4. Lifestyle Considerations: Maintain a healthy diet, engage in regular exercise, and avoid alcohol to help support your overall health and immune function.
5. Inform About Other Medications: Always disclose any other medications, supplements, or herbal products you are taking to prevent potential interactions.

Important Notes

• Isentress is typically used as part of a comprehensive HIV treatment regimen, often in combination with other antiretroviral medications.
• Discuss any concerns or questions regarding treatment options, effectiveness, or side effects with your healthcare provider.

If you have more specific questions about Isentress (Raltegravir) or need additional information, feel free to ask!