Lamivir S is a fixed-dose combination tablet that contains 150 mg of Lamivudine and 30 mg of Stavudine. It is an antiretroviral medication used to treat human immunodeficiency virus (HIV) infection in adults and children.
Composition:
- Lamivudine: 150 mg
- Stavudine: 30 mg
- Tablet core: croscarmellose sodium, lactose monohydrate, magnesium stearate
- Film coating: hypromellose, polyethylene glycol, titanium dioxide
Mechanism of Action:
Lamivir S works by inhibiting the activity of HIV reverse transcriptase, an enzyme necessary for the virus to replicate. Lamivudine (3TC) is a nucleoside analog that inhibits the reverse transcriptase enzyme, while Stavudine (d4T) is a nucleoside analog that inhibits the viral DNA polymerase.
Uses:
Lamivir S is used to treat HIV infection in adults and children. It is recommended for patients who have not previously received antiretroviral therapy or who have failed other antiretroviral regimens.
Dosage:
The recommended dosage of Lamivir S is one tablet once daily, taken with food.
Side Effects:
Common side effects of Lamivir S include:
- Nausea
- Vomiting
- Diarrhea
- Fatigue
- Headache
- Abdominal pain
- Increased liver enzymes
- Increased blood lipids
- Kidney damage (in patients with pre-existing kidney disease)
Recommendation:
Lamivir S should be used under the guidance of a healthcare professional. Patients should be monitored regularly for liver function tests, lipid profiles, and glucose levels.
Important Note:
- Lamivir S is not recommended for use in patients with severe liver disease (Child-Pugh C).
- Patients with pre-existing kidney disease should be monitored closely for signs of kidney damage or toxicity.
- Patients taking other medications, including antiretroviral agents, may be at risk for interactions with Lamivir S.
- The safety and efficacy of Lamivir S in pregnant or lactating women have not been established.
- Lamivir S is not recommended for use in children under 6 months of age.
- Patients should be counseled on the importance of taking concomitant therapy as prescribed by their healthcare provider.
- Patients should be monitored for neuropsychiatric symptoms, such as depression, anxiety, and sleep disorders.
It is essential to follow the recommended dosage and monitoring guidelines to ensure safe and effective treatment.
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