Lazid

Lazid tablets are a combination antiretroviral medication used in the treatment and management of HIV-1 infection. The tablets contain lamivudine and zidovudine, which are both nucleoside reverse transcriptase inhibitors (NRTIs). These two drugs work together to reduce the amount of HIV in the blood and increase CD4 (T) cell counts, thereby improving immune function.

Composition:

Each Lazid tablet contains:

• Lamivudine: 150 mg
• Zidovudine: 300 mg

Uses:

Lazid tablets are used for:

• The treatment of HIV-1 infection in combination with other antiretroviral agents.
• They help to lower the viral load in the body and slow the progression of the disease.

Mechanism of Action:

Both lamivudine and zidovudine are nucleoside reverse transcriptase inhibitors (NRTIs). They work by:

• Inhibiting the reverse transcriptase enzyme, which is necessary for the conversion of viral RNA into DNA.
• This inhibition prevents the replication of the virus within the host cells, thus reducing the viral load and slowing the progression of HIV.

Dosage:

• Adults and Adolescents (weighing at least 30 kg): One tablet taken orally twice daily.
• Children: The dosage varies based on weight and should be determined by a healthcare provider.

Side Effects:

Common side effects:

• Headache
• Nausea
• Fatigue
• Vomiting
• Diarrhea
• Abdominal pain

Less common but serious side effects:

• Anemia (low red blood cell count)
• Neutropenia (low white blood cell count)
• Myopathy (muscle damage)
• Lactic acidosis
• Hepatomegaly with steatosis (enlarged liver with fat accumulation)
• Pancreatitis

Recommendations:

• Take Lazid exactly as prescribed by your healthcare provider.
• Do not miss doses or adjust the dose on your own.
• Take the medication at the same time each day to maintain consistent drug levels.
• Inform your healthcare provider about all other medications and supplements you are taking to avoid potential drug interactions.

Important Note:

• Do not stop taking Lazid without consulting your healthcare provider, as this may result in an increase in viral load and potential treatment failure.
• Regularly monitor blood counts and other laboratory parameters to detect any potential side effects early.
• Pregnant women or those planning to become pregnant should inform their healthcare provider to discuss the potential risks and benefits.
• Store the medication at room temperature, away from moisture and direct light.
• Maintain regular follow-up appointments with your healthcare provider for monitoring and management of your HIV infection.
• Discuss any new symptoms or side effects with your healthcare provider immediately.

This comprehensive overview covers the key aspects of Lazid (Lamivudine and Zidovudine Tablets). For any specific concerns or questions, always consult your healthcare provider.