Nelvir

Nelvir (nelfinavir) is an antiretroviral medication used to treat HIV (Human Immunodeficiency Virus) infection. Nelfinavir is a protease inhibitor that helps to decrease the amount of HIV in the body, thus improving the immune system’s function and reducing the risk of developing complications associated with HIV infection.

Composition:

Each tablet of Nelvir contains:

• Nelfinavir 250 mg

Mechanism of Action:

Nelfinavir works by inhibiting the action of protease, an enzyme that HIV needs to multiply. By blocking this enzyme, nelfinavir enables the production of non-infectious viral particles, thereby reducing the amount of HIV in the body. This helps improve immune function and decrease the likelihood of HIV-related illnesses.

Uses:

• Treatment of HIV Infection: Used in combination with other antiretroviral agents to treat HIV-1 infection.

Dosage:

The dosage of Nelvir should be determined by a healthcare provider. The typical dosage recommendation is:

• Adults and Adolescents:
  • 1250 mg (five 250 mg tablets) twice daily, with food.
  • Alternatively, the dosage can be 750 mg (three 250 mg tablets) three times daily, with food.
• Children (age and weight-based dosing):
  • The dosage should be adjusted according to the child’s weight and prescribed by a healthcare provider.

  • Side Effects

    While Nelvir (nelfinavir 250 mg) is effective in managing HIV infection, it may cause side effects. It’s important for patients to be aware of these potential side effects and to contact their healthcare provider if they experience any unusual symptoms.

    Common Side Effects:

    • Diarrhea
    • Nausea
    • Stomach pain
    • Gas (flatulence)
    • Rash
    • Fatigue
    • Headache

    Less Common but Serious Side Effects:

    • Hepatotoxicity: Liver problems, which can be severe. Symptoms include:
      • Jaundice (yellowing of the skin or eyes)
      • Dark urine
      • Severe abdominal pain
    • Diabetes and Hyperglycemia: New onset or worsening of diabetes; symptoms include:
      • Increased hunger or thirst
      • Frequent urination
      • Unexplained weight loss
    • Immune Reconstitution Syndrome: As the immune system recovers, it can become overactive and cause inflammatory reactions to previous infections.
    • Lactic Acidosis: A rare but potentially life-threatening build-up of lactic acid in the blood. Symptoms include:
      • Unusual muscle pain
      • Trouble breathing
      • Stomach pain with nausea and vomiting
      • Feeling weak, tired, or dizzy
      • Cold or blue hands and feet
    • Lipodystrophy: Changes in body fat distribution

    • Recommendations:

      • Adherence to Therapy:
        • Take Nelvir exactly as prescribed by your healthcare provider. Do not skip doses or stop taking the medication without consulting your healthcare provider as this can lead to drug resistance and treatment failure.
        • Always take Nelvir with food to improve absorption and effectiveness.
      • Monitoring:
        • Regular follow-up appointments are essential. Your healthcare provider may conduct periodic blood tests to monitor your liver function, blood sugar levels, and overall health.
      • Drug Interactions:
        • Inform your healthcare provider about all other medications you’re taking, including over-the-counter drugs, vitamins, and herbal supplements, as nelfinavir can interact with other medications.
      • Hydration and Nutrition:
        • Maintain adequate hydration and a balanced diet to help manage side effects such as diarrhea.
      • Managing Side Effects:
        • For diarrhea, your healthcare provider may recommend over-the-counter remedies or prescribe specific medications.
        • Report any severe side effects, such as symptoms of liver problems or lactic acidosis, to your healthcare provider immediately.

      Important Notes:

      • Resistance:
        • Poor adherence to the prescribed regimen can lead to the development of resistant strains of HIV. It is crucial to take this medication consistently and correctly.
      • Pregnancy and Breastfeeding:
        • Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Your provider will discuss the potential risks