Stavir 40mg

Stavir is a prescription-only antiretroviral medication that contains Stavudine (30mg), a nucleoside reverse transcriptase inhibitor (NRTI). It is used in combination with other antiretroviral agents to treat HIV infection in adults and adolescents.

Mechanism of Action:

Stavudine works by inhibiting the activity of HIV reverse transcriptase, an enzyme necessary for the virus to replicate. It is converted into its active form, d4T, which is then incorporated into the growing DNA chain, terminating the synthesis of new viral DNA.

Uses:

Stavir is used in combination with other antiretroviral agents to treat HIV infection in adults and adolescents who have not previously received antiretroviral therapy or who have failed other antiretroviral regimens.

Dosage:

The recommended dosage of Stavir is 30mg taken twice daily, with food. The dose may be adjusted based on the patient’s weight and renal function.

Side Effects:

Common side effects of Stavir include:

• Headache
• Nausea
• Vomiting
• Diarrhea
• Fatigue
• Dizziness
• Insomnia
• Rash
• Abnormal dreams
• Increased blood lipids
• Neuropathy (nerve damage)
• Lactic acidosis (build-up of lactic acid in the blood)

Recommendation:

Stavir should be used under the guidance of a healthcare professional. Patients should be monitored regularly for liver function tests, lipid profiles, and glucose levels.

Important Note:

• Stavir is not recommended for use in patients with severe liver disease (Child-Pugh C).
• Patients with pre-existing kidney disease should be monitored closely for signs of kidney damage or toxicity.
• Patients taking other medications, including antiretroviral agents, may be at risk for interactions with Stavir.
• The safety and efficacy of Stavir in pregnant or lactating women have not been established.
• Patients should be counseled on the importance of taking concomitant therapy as prescribed by their healthcare provider.
• Patients should be monitored for neuropsychiatric symptoms, such as depression, anxiety, and sleep disorders.

Special Precautions:

• Stavir should be taken with food to improve absorption.
• Patients with diabetes should be monitored closely for changes in blood glucose levels.
• Patients with pre-existing kidney disease should be monitored closely for signs of kidney damage or toxicity.
• Patients with liver disease should be monitored closely for signs of liver damage or toxicity.
• Patients taking other medications that may interact with Stavir should be monitored closely for signs of toxicity or adverse effects.

Contraindications:

Stavir is contraindicated in patients who are allergic to any of its ingredients. It is also contraindicated in patients with severe liver disease (Child-Pugh C).

Clinical Trials:

Stavir has been studied in clinical trials in combination with other antiretroviral agents. The results of these trials have shown that Stavir is effective in suppressing HIV replication and improving patient outcomes.