Tenvir L

Tenvir L is a fixed-dose combination tablet that contains two antiretroviral medications:

• Lamivudine (300mg): a nucleoside reverse transcriptase inhibitor (NRTI)
• Tenofovir disoproxil fumarate (300mg): a nucleotide reverse transcriptase inhibitor (NtRTI)

Mechanism of Action:

The combination of Lamivudine and Tenofovir disoproxil fumarate works in the following way:

• Lamivudine inhibits the activity of HIV reverse transcriptase, an enzyme necessary for the virus to replicate.
• Tenofovir disoproxil fumarate also inhibits the activity of HIV reverse transcriptase, preventing the virus from replicating.

Uses:

Tenvir L is used to treat HIV infection in adults and adolescents. It is recommended for patients who have not previously received antiretroviral therapy or who have failed other antiretroviral regimens.

Dosage:

The recommended dosage of Tenvir L is one tablet taken once daily, with food.

Side Effects:

Common side effects of Tenvir L include:

• Headache
• Nausea
• Vomiting
• Diarrhea
• Fatigue
• Dizziness
• Insomnia
• Rash
• Abnormal dreams
• Increased blood lipids
• Neuropathy (nerve damage)
• Lactic acidosis (build-up of lactic acid in the blood)
• Stevens-Johnson syndrome (a severe skin reaction)
• Anaphylaxis (a severe allergic reaction)

Recommendation:

Tenvir L should be used under the guidance of a healthcare professional. Patients should be monitored regularly for liver function tests, lipid profiles, and glucose levels.

Important Note:

• Tenvir L is not recommended for use in patients with severe liver disease (Child-Pugh C).
• Patients with pre-existing kidney disease should be monitored closely for signs of kidney damage or toxicity.
• Patients taking other medications, including antiretroviral agents, may be at risk for interactions with Tenvir L.
• The safety and efficacy of Tenvir L in pregnant or lactating women have not been established.
• Patients should be counseled on the importance of taking concomitant therapy as prescribed by their healthcare provider.
• Patients should be monitored for neuropsychiatric symptoms, such as depression, anxiety, and sleep disorders.

Special Precautions:

• Tenvir L should be taken with food to improve absorption.
• Patients with diabetes should be monitored closely for changes in blood glucose levels.
• Patients with pre-existing kidney disease should be monitored closely for signs of kidney damage or toxicity.
• Patients with liver disease should be monitored closely for signs of liver damage or toxicity.
• Patients taking other medications that may interact with Tenvir L should be monitored closely for signs of toxicity or adverse effects.

Contraindications:

Tenvir L is contraindicated in patients who are allergic to any of its ingredients. It is also contraindicated in patients with severe liver disease (Child-Pugh C).

Clinical Trials:

Tenvir L has been studied in clinical trials in combination with other antiretroviral agents. The results of these trials have shown that Tenvir L is effective in suppressing HIV replication and improving patient outcomes.