FOLIGRAF 150 is a highly purified recombinant FSH (rFSH) injection used for ovulation induction and assisted reproductive technologies (ART) like IVF. It contains follitropin alfa, a biosynthetic form of human FSH, produced through genetic engineering.
Composition
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Active Ingredient:Â Follitropin alfa 150 IUÂ (recombinant human FSH).
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Form:
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Lyophilized powder (with solvent for reconstitution).
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Prefilled pen (ready-to-use solution).
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Excipients: Sucrose, sodium citrate, polysorbate 20.
(No LH activity, minimal protein contaminants.)
Mechanism of Action
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Stimulates ovarian follicular growth (in women).
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Supports spermatogenesis (in men with hypogonadotropic hypogonadism).
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Used in combination with GnRH agonists/antagonists in ART cycles.
Dosage & Administration
For Women
Indication | Starting Dose | Adjustment | Max Dose |
---|---|---|---|
Ovulation Induction | 75–150 IU/day | ↑ by 37.5–75 IU every 7 days | 225 IU/day |
IVF/ICSI | 150–300 IU/day | Based on response | 450 IU/day |
For Men
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150–300 IU SC 2–3x/week (with hCG).
Administration
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Reconstitute powder (if using vials) with provided solvent.
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Inject subcutaneously (preferred) or intramuscularly.
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Rotate injection sites (to avoid lipoatrophy).
Uses (Indications)
✅ Anovulatory infertility (e.g., PCOS).
✅ Controlled ovarian stimulation (IVF/IUI).
✅ Male infertility (hypogonadotropic hypogonadism).
Storage & Stability
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Unopened vials/pens: 2–8°C (refrigerate; do not freeze).
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After reconstitution: Use immediately.
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Prefilled pens: Store refrigerated; stable for 28 days at room temp after first use.
Key Recommendations
✔ Monitor with:
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Ultrasound (follicle size/number).
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Estradiol levels (prevent OHSS).
✔ Start low in PCOS (high OHSS risk).
✔ Use GnRH antagonist protocol for high responders.
Important Safety Notes
⚠ Ovarian Hyperstimulation Syndrome (OHSS) Risk – Requires close monitoring.
⚠ Multiple Pregnancy Risk – Higher with fertility treatments.
âš Â Contraindications:
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Ovarian/testicular tumors.
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Pregnancy.
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Uncontrolled thyroid/adrenal disorders.
Comparison with Other FSH Preparations
Feature | FOLIGRAF 150 (rFSH) | hMG (HUMOG) | Clomiphene Citrate |
---|---|---|---|
Type | Recombinant FSH | Urinary FSH+LH | Oral anti-estrogen |
Purity | >99% | ~95% | N/A |
Male Use | Yes | Yes | No |
Cost | High | Moderate | Low |
Conclusion
FOLIGRAF 150 is a high-purity rFSH for ovulation induction & ART, offering consistent dosing and reduced immunogenicity vs. urinary FSH.
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