ESTRABET is an estrogen therapy medication containing Estradiol Valerate, a bioidentical estrogen used for menopausal symptom relief, hormone replacement therapy (HRT), and certain gynecological conditions.
Composition
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Active Ingredient: Estradiol Valerate (1 mg or 2 mg tablets).
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Inactive Ingredients: Lactose, maize starch, povidone, magnesium stearate.
Mechanism of Action
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Estradiol Valerate converts to estradiol in the body, binding to estrogen receptors.
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Relieves menopausal symptoms (hot flashes, vaginal dryness).
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Prevents bone loss (osteoporosis) in postmenopausal women.
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Regulates menstrual cycles in hypoestrogenic conditions.
Dosage & Administration
Common Indications & Dosing
Condition | Dosage | Duration |
---|---|---|
Menopausal symptoms | 1–2 mg/day | Continuous or cyclic (21 days on, 7 days off) |
Postmenopausal osteoporosis | 0.5–1 mg/day | Long-term (with progesterone if uterus intact) |
Hypoestrogenism | 1–2 mg/day | Cyclic (3 weeks on, 1 week off) |
Administration Notes
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Take at the same time daily for consistent hormone levels.
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With or without food (food may reduce nausea).
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For women with a uterus, always combine with progesterone to prevent endometrial hyperplasia.
Indications
✅ Relief of menopausal symptoms (hot flashes, night sweats).
✅ Prevention of postmenopausal osteoporosis.
✅ Female hypogonadism (estrogen deficiency).
✅ Primary ovarian failure.
Storage & Stability
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Store below 25°C, protect from moisture & light.
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Keep in original packaging to prevent degradation.
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Shelf life: Typically 2–3 years.
Key Recommendations
✔ Lowest effective dose for shortest duration (↑ risk of breast cancer with long-term use).
✔ Monitor blood pressure (estrogen can cause fluid retention).
✔ Annual breast exams & mammograms (due to estrogen-dependent cancer risk).
Important Safety Notes
âš Â Contraindications:
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Breast/endometrial cancer (estrogen-sensitive tumors).
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Active thromboembolism (DVT, stroke history).
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Severe liver disease.
⚠ Pregnancy (Category X): Absolutely contraindicated (risk of fetal harm).
âš Â Side Effects:
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Common: Breast tenderness, bloating, nausea.
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Serious: Blood clots, stroke, gallbladder disease.
Comparison with Other Estrogens
Feature | ESTRABET (Estradiol Valerate) | Conjugated Estrogens (Premarin) | Transdermal Estradiol |
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Type | Bioidentical | Synthetic (horse-derived) | Bioidentical |
Dosing | Oral (daily) | Oral (daily) | Patch/gel (weekly/daily) |
Thrombosis Risk | Moderate | High | Lower (avoids first-pass liver) |
Breast Cancer Risk | Dose-dependent | Higher risk | Possibly lower |
Conclusion
ESTRABET is an effective oral estrogen for menopausal symptom relief & bone protection, but must be used cautiously due to thrombosis & cancer risks
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