HALD SR 200MG

Women Health

Description
Shipping Options
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HALD SR 200MG is a long-acting intramuscular (IM) antipsychotic injection containing Haloperidol Decanoate, used for maintenance therapy in schizophrenia and other psychotic disorders in patients who require prolonged treatment.

Composition

Active Ingredient: Haloperidol Decanoate 200 mg/mL (in sesame oil base).
Vehicle: Sesame oil, benzyl alcohol (preservative).

Mechanism of Action

Potent dopamine (D2) receptor antagonist in the CNS.
Also blocks serotonin (5-HT2), alpha-adrenergic, and histamine (H1) receptors to a lesser extent.
Long-acting depot formulation: Slowly releases haloperidol over 3–4 weeks.

Dosage & Administration

Initial Dose (Stabilized Patients):

10–15x the equivalent daily oral dose (e.g., if oral dose = 10 mg/day → 100–150 mg IM).
Max initial dose: 200 mg IM.

Maintenance Dose:

50–200 mg IM every 4 weeks (adjust based on response).

Administration:

Deep IM injection (gluteal muscle preferred).
Do not administer IV or subcutaneously (risk of oil embolism).

Switching from Oral to Depot:

Overlap oral haloperidol for 4–8 weeks to ensure stability.

Uses (Indications)

✅ Maintenance therapy for schizophrenia (non-adherent patients). ✅ Chronic psychotic disorders (e.g., paranoid schizophrenia). ✅ Tourette’s syndrome (alternative when oral therapy fails).

Storage & Stability

Store at 15–30°C, protect from light.
Do not freeze (oil base may solidify).
Stable for up to 3 months after first use if stored properly.

Key Recommendations

✔ Monitor for EPS (extrapyramidal symptoms): Dystonia, akathisia, tardive dyskinesia. ✔ Assess QT prolongation risk (ECG monitoring in high-risk patients). ✔ Avoid abrupt withdrawal (risk of relapse). ✔ Use lowest effective dose (elderly patients are more sensitive).

Important Notes

⚠ Black Box Warning:

Increased mortality in elderly dementia patients (not approved for dementia-related psychosis).
QT prolongation & torsades de pointes (avoid in cardiac disease).

⚠ Contraindications:

Parkinson’s disease, Lewy body dementia (worsens motor symptoms).
Severe CNS depression, coma.

⚠ Pregnancy (Category C): Risk of neonatal EPS; use only if benefits justify risks.

Side Effects

Common (≥10%)	Serious (<1%)
– EPS (dystonia, tremors)	– Neuroleptic malignant syndrome (NMS)
– Sedation	– Severe QT prolongation
– Dry mouth	– Tardive dyskinesia (irreversible)
– Weight gain	– Seizures

Drug Interactions

Interacting Drug	Effect	Management
CYP3A4 inhibitors (ketoconazole)	↑ Haloperidol levels	Monitor for toxicity
CYP2D6 inhibitors (fluoxetine)	↑ Haloperidol levels	Reduce dose
QT-prolonging drugs (amiodarone)	↑ Arrhythmia risk	Avoid combo
CNS depressants (benzodiazepines)	↑ Sedation	Caution

Comparison with Other Depot Antipsychotics

Feature	HALD SR (Haloperidol)	Risperidone Consta	Fluphenazine Decanoate
Dosing Interval	Every 4 weeks	Every 2 weeks	Every 2–4 weeks
EPS Risk	High	Moderate	High
QT Risk	High	Low	Moderate
Cost	Low	High	Moderate

Conclusion

HALD SR 200MG is a cost-effective depot antipsychotic for chronic schizophrenia, but requires careful monitoring for EPS and cardiac effects.

Composition

Active Ingredient: Haloperidol Decanoate 200 mg/mL (in sesame oil base).
Vehicle: Sesame oil, benzyl alcohol (preservative).

Mechanism of Action

Potent dopamine (D2) receptor antagonist in the CNS.
Also blocks serotonin (5-HT2), alpha-adrenergic, and histamine (H1) receptors to a lesser extent.
Long-acting depot formulation: Slowly releases haloperidol over 3–4 weeks.

Dosage & Administration

Initial Dose (Stabilized Patients):

10–15x the equivalent daily oral dose (e.g., if oral dose = 10 mg/day → 100–150 mg IM).
Max initial dose: 200 mg IM.

Maintenance Dose:

50–200 mg IM every 4 weeks (adjust based on response).

Administration:

Deep IM injection (gluteal muscle preferred).
Do not administer IV or subcutaneously (risk of oil embolism).

Switching from Oral to Depot:

Overlap oral haloperidol for 4–8 weeks to ensure stability.

Uses (Indications)

✅ Maintenance therapy for schizophrenia (non-adherent patients).
✅ Chronic psychotic disorders (e.g., paranoid schizophrenia).
✅ Tourette’s syndrome (alternative when oral therapy fails).

Storage & Stability

Store at 15–30°C, protect from light.
Do not freeze (oil base may solidify).
Stable for up to 3 months after first use if stored properly.

Key Recommendations

✔ Monitor for EPS (extrapyramidal symptoms): Dystonia, akathisia, tardive dyskinesia.
✔ Assess QT prolongation risk (ECG monitoring in high-risk patients).
✔ Avoid abrupt withdrawal (risk of relapse).
✔ Use lowest effective dose (elderly patients are more sensitive).

Important Notes

⚠ Black Box Warning:

Increased mortality in elderly dementia patients (not approved for dementia-related psychosis).
QT prolongation & torsades de pointes (avoid in cardiac disease).

⚠ Contraindications:

Parkinson’s disease, Lewy body dementia (worsens motor symptoms).
Severe CNS depression, coma.

⚠ Pregnancy (Category C): Risk of neonatal EPS; use only if benefits justify risks.

Side Effects

Common (≥10%)	Serious (<1%)
– EPS (dystonia, tremors)	– Neuroleptic malignant syndrome (NMS)
– Sedation	– Severe QT prolongation
– Dry mouth	– Tardive dyskinesia (irreversible)
– Weight gain	– Seizures

Drug Interactions

Interacting Drug	Effect	Management
CYP3A4 inhibitors (ketoconazole)	↑ Haloperidol levels	Monitor for toxicity
CYP2D6 inhibitors (fluoxetine)	↑ Haloperidol levels	Reduce dose
QT-prolonging drugs (amiodarone)	↑ Arrhythmia risk	Avoid combo
CNS depressants (benzodiazepines)	↑ Sedation	Caution

Comparison with Other Depot Antipsychotics

Feature	HALD SR (Haloperidol)	Risperidone Consta	Fluphenazine Decanoate
Dosing Interval	Every 4 weeks	Every 2 weeks	Every 2–4 weeks
EPS Risk	High	Moderate	High
QT Risk	High	Low	Moderate
Cost	Low	High	Moderate

Conclusion

HALD SR 200MG is a cost-effective depot antipsychotic for chronic schizophrenia, but requires careful monitoring for EPS and cardiac effects.

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Composition

Active Ingredient: Haloperidol Decanoate 200 mg/mL (in sesame oil base).
Vehicle: Sesame oil, benzyl alcohol (preservative).

Mechanism of Action

Potent dopamine (D2) receptor antagonist in the CNS.
Also blocks serotonin (5-HT2), alpha-adrenergic, and histamine (H1) receptors to a lesser extent.
Long-acting depot formulation: Slowly releases haloperidol over 3–4 weeks.

Dosage & Administration

Initial Dose (Stabilized Patients):

10–15x the equivalent daily oral dose (e.g., if oral dose = 10 mg/day → 100–150 mg IM).
Max initial dose: 200 mg IM.

Maintenance Dose:

50–200 mg IM every 4 weeks (adjust based on response).

Administration:

Deep IM injection (gluteal muscle preferred).
Do not administer IV or subcutaneously (risk of oil embolism).

Switching from Oral to Depot:

Overlap oral haloperidol for 4–8 weeks to ensure stability.

Uses (Indications)

✅ Maintenance therapy for schizophrenia (non-adherent patients).
✅ Chronic psychotic disorders (e.g., paranoid schizophrenia).
✅ Tourette’s syndrome (alternative when oral therapy fails).

Storage & Stability

Store at 15–30°C, protect from light.
Do not freeze (oil base may solidify).
Stable for up to 3 months after first use if stored properly.

Key Recommendations

✔ Monitor for EPS (extrapyramidal symptoms): Dystonia, akathisia, tardive dyskinesia.
✔ Assess QT prolongation risk (ECG monitoring in high-risk patients).
✔ Avoid abrupt withdrawal (risk of relapse).
✔ Use lowest effective dose (elderly patients are more sensitive).

Important Notes

⚠ Black Box Warning:

Increased mortality in elderly dementia patients (not approved for dementia-related psychosis).
QT prolongation & torsades de pointes (avoid in cardiac disease).

⚠ Contraindications:

Parkinson’s disease, Lewy body dementia (worsens motor symptoms).
Severe CNS depression, coma.

⚠ Pregnancy (Category C): Risk of neonatal EPS; use only if benefits justify risks.

Side Effects

Common (≥10%)	Serious (<1%)
– EPS (dystonia, tremors)	– Neuroleptic malignant syndrome (NMS)
– Sedation	– Severe QT prolongation
– Dry mouth	– Tardive dyskinesia (irreversible)
– Weight gain	– Seizures

Drug Interactions

Interacting Drug	Effect	Management
CYP3A4 inhibitors (ketoconazole)	↑ Haloperidol levels	Monitor for toxicity
CYP2D6 inhibitors (fluoxetine)	↑ Haloperidol levels	Reduce dose
QT-prolonging drugs (amiodarone)	↑ Arrhythmia risk	Avoid combo
CNS depressants (benzodiazepines)	↑ Sedation	Caution

Comparison with Other Depot Antipsychotics

Feature	HALD SR (Haloperidol)	Risperidone Consta	Fluphenazine Decanoate
Dosing Interval	Every 4 weeks	Every 2 weeks	Every 2–4 weeks
EPS Risk	High	Moderate	High
QT Risk	High	Low	Moderate
Cost	Low	High	Moderate

Conclusion

HALD SR 200MG is a cost-effective depot antipsychotic for chronic schizophrenia, but requires careful monitoring for EPS and cardiac effects.

Reviews

There are no reviews yet.

Be the first to review “HALD SR 200MG”

Description
Reviews (0)

Composition

Active Ingredient: Haloperidol Decanoate 200 mg/mL (in sesame oil base).
Vehicle: Sesame oil, benzyl alcohol (preservative).

Mechanism of Action

Potent dopamine (D2) receptor antagonist in the CNS.
Also blocks serotonin (5-HT2), alpha-adrenergic, and histamine (H1) receptors to a lesser extent.
Long-acting depot formulation: Slowly releases haloperidol over 3–4 weeks.

Dosage & Administration

Initial Dose (Stabilized Patients):

10–15x the equivalent daily oral dose (e.g., if oral dose = 10 mg/day → 100–150 mg IM).
Max initial dose: 200 mg IM.

Maintenance Dose:

50–200 mg IM every 4 weeks (adjust based on response).

Administration:

Deep IM injection (gluteal muscle preferred).
Do not administer IV or subcutaneously (risk of oil embolism).

Switching from Oral to Depot:

Overlap oral haloperidol for 4–8 weeks to ensure stability.

Uses (Indications)

✅ Maintenance therapy for schizophrenia (non-adherent patients).
✅ Chronic psychotic disorders (e.g., paranoid schizophrenia).
✅ Tourette’s syndrome (alternative when oral therapy fails).

Storage & Stability

Store at 15–30°C, protect from light.
Do not freeze (oil base may solidify).
Stable for up to 3 months after first use if stored properly.

Key Recommendations

✔ Monitor for EPS (extrapyramidal symptoms): Dystonia, akathisia, tardive dyskinesia.
✔ Assess QT prolongation risk (ECG monitoring in high-risk patients).
✔ Avoid abrupt withdrawal (risk of relapse).
✔ Use lowest effective dose (elderly patients are more sensitive).

Important Notes

⚠ Black Box Warning:

Increased mortality in elderly dementia patients (not approved for dementia-related psychosis).
QT prolongation & torsades de pointes (avoid in cardiac disease).

⚠ Contraindications:

Parkinson’s disease, Lewy body dementia (worsens motor symptoms).
Severe CNS depression, coma.

⚠ Pregnancy (Category C): Risk of neonatal EPS; use only if benefits justify risks.

Side Effects

Common (≥10%)	Serious (<1%)
– EPS (dystonia, tremors)	– Neuroleptic malignant syndrome (NMS)
– Sedation	– Severe QT prolongation
– Dry mouth	– Tardive dyskinesia (irreversible)
– Weight gain	– Seizures

Drug Interactions

Interacting Drug	Effect	Management
CYP3A4 inhibitors (ketoconazole)	↑ Haloperidol levels	Monitor for toxicity
CYP2D6 inhibitors (fluoxetine)	↑ Haloperidol levels	Reduce dose
QT-prolonging drugs (amiodarone)	↑ Arrhythmia risk	Avoid combo
CNS depressants (benzodiazepines)	↑ Sedation	Caution

Comparison with Other Depot Antipsychotics

Feature	HALD SR (Haloperidol)	Risperidone Consta	Fluphenazine Decanoate
Dosing Interval	Every 4 weeks	Every 2 weeks	Every 2–4 weeks
EPS Risk	High	Moderate	High
QT Risk	High	Low	Moderate
Cost	Low	High	Moderate

Conclusion

HALD SR 200MG is a cost-effective depot antipsychotic for chronic schizophrenia, but requires careful monitoring for EPS and cardiac effects.

Reviews

There are no reviews yet.

Be the first to review “HALD SR 200MG”

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