ORGAMED

Women Health

Description
Shipping Options
Customer Reviews

Brand Name: ORGAMED
Generic Name: Estradiol Hemihydrate
Therapeutic Class: Transdermal Estrogen Therapy
Delivery System: Matrix-type patch (adhesive layer contains active drug)
Available Strengths:
- 25 μg/day (7.6 mg estradiol)
- 50 μg/day (15.2 mg estradiol)
- 75 μg/day (22.8 mg estradiol)
- 100 μg/day (30.4 mg estradiol)

2. COMPOSITION

Component	Function
Estradiol Hemihydrate	Active ingredient
Polyacrylate adhesive	Matrix carrier
Polyester film	Backing layer
Silicone-coated release liner	Protective layer

(Alcohol-free formulation, suitable for sensitive skin)

3. MECHANISM OF ACTION

✔ Continuous transdermal delivery of 17β-estradiol:

Avoids first-pass hepatic metabolism
Maintains stable serum levels (no peaks/troughs) ✔ Therapeutic Effects:
Relieves vasomotor symptoms (hot flashes/night sweats)
Prevents postmenopausal bone loss
Improves urogenital atrophy
May enhance mood/cognitive function

4. DOSAGE & ADMINISTRATION

Standard Regimens

Clinical Scenario	Initial Dose	Maintenance Dose	Patch Change Frequency
Vasomotor Symptoms	25-50 μg/day	Lowest effective dose	Twice weekly
Osteoporosis Prevention	50 μg/day	Long-term	Twice weekly
With Progestin (Intact Uterus)	Add oral/transdermal progestin 12-14 days/month

Application Guide

Site Selection: Clean, dry skin on lower abdomen or buttock
Rotation: Avoid same site for ≥1 week
Adhesion: Press firmly for 10 seconds
Water Resistance: Safe for bathing/swimming

5. INDICATIONS

✅ Moderate-to-severe menopausal symptoms ✅ Prevention of postmenopausal osteoporosis ✅ Hypoestrogenism (surgical/natural menopause)

6. STORAGE CONDITIONS

Unopened Pouches: Below 25°C (do not refrigerate)
After Removal from Pouch: Apply immediately
Shelf Life: 36 months

7. KEY RECOMMENDATIONS

✔ Start therapy within 10 years of menopause for cardiovascular benefit ✔ Annual breast/endometrial monitoring (if uterus present) ✔ Consider lower doses (25 μg) for older women (>65 years) ✔ Patch-free interval not required (continuous dosing)

8. IMPORTANT SAFETY NOTES

Black Box Warnings

⚠ Endometrial Cancer:

Unopposed estrogen increases risk 8-10 fold
Requires progestin co-therapy in non-hysterectomized women

⚠ Cardiovascular Risks:

Lower than oral estrogens but still present

⚠ Dementia Risk: Increased in women >65 years

Contraindications

❌ Active arterial thromboembolism ❌ Estrogen-sensitive malignancies ❌ Severe hepatic impairment

Adverse Effects

Local (≥5%)	Systemic (<5%)
Skin irritation	Breast tenderness
Pruritus	Headache
Erythema	Fluid retention

9. COMPARISON WITH OTHER HRT FORMULATIONS

Parameter	ORGAMED Patch	Oral Estradiol	Vaginal Estrogen
VTE Risk	+	+++	+
Hepatic Impact	Minimal	Significant	Minimal
Dosing Frequency	2x weekly	Daily	2-3x weekly
Libido Effect	Neutral	Neutral	Local benefit

10. PATIENT COUNSELING POINTS

✔ Proper application technique:

Avoid breasts/waistline areas
Remove old patch before applying new

✔ Warning signs requiring medical attention:

Severe skin reactions
New breast lumps
Visual disturbances

✔ Advantages over oral therapy:

Lower stroke risk
No triglyceride elevation
Better for hypertension patients

CONCLUSION

ORGAMED provides stable, physiologic estrogen replacement with improved safety profile versus oral HRT. Its twice-weekly dosing and lower thrombotic risk make it preferable for many menopausal women, especially those with cardiovascular risk factors.

Brand Name: ORGAMED
Generic Name: Estradiol Hemihydrate
Therapeutic Class: Transdermal Estrogen Therapy
Delivery System: Matrix-type patch (adhesive layer contains active drug)
Available Strengths:
- 25 μg/day (7.6 mg estradiol)
- 50 μg/day (15.2 mg estradiol)
- 75 μg/day (22.8 mg estradiol)
- 100 μg/day (30.4 mg estradiol)

2. COMPOSITION

Component	Function
Estradiol Hemihydrate	Active ingredient
Polyacrylate adhesive	Matrix carrier
Polyester film	Backing layer
Silicone-coated release liner	Protective layer

(Alcohol-free formulation, suitable for sensitive skin)

3. MECHANISM OF ACTION

✔ Continuous transdermal delivery of 17β-estradiol:

Avoids first-pass hepatic metabolism
Maintains stable serum levels (no peaks/troughs)
✔ Therapeutic Effects:
Relieves vasomotor symptoms (hot flashes/night sweats)
Prevents postmenopausal bone loss
Improves urogenital atrophy
May enhance mood/cognitive function

4. DOSAGE & ADMINISTRATION

Standard Regimens

Clinical Scenario	Initial Dose	Maintenance Dose	Patch Change Frequency
Vasomotor Symptoms	25-50 μg/day	Lowest effective dose	Twice weekly
Osteoporosis Prevention	50 μg/day	Long-term	Twice weekly
With Progestin (Intact Uterus)	Add oral/transdermal progestin 12-14 days/month

Application Guide

Site Selection: Clean, dry skin on lower abdomen or buttock
Rotation: Avoid same site for ≥1 week
Adhesion: Press firmly for 10 seconds
Water Resistance: Safe for bathing/swimming

5. INDICATIONS

✅ Moderate-to-severe menopausal symptoms
✅ Prevention of postmenopausal osteoporosis
✅ Hypoestrogenism (surgical/natural menopause)

6. STORAGE CONDITIONS

Unopened Pouches: Below 25°C (do not refrigerate)
After Removal from Pouch: Apply immediately
Shelf Life: 36 months

7. KEY RECOMMENDATIONS

✔ Start therapy within 10 years of menopause for cardiovascular benefit
✔ Annual breast/endometrial monitoring (if uterus present)
✔ Consider lower doses (25 μg) for older women (>65 years)
✔ Patch-free interval not required (continuous dosing)

8. IMPORTANT SAFETY NOTES

Black Box Warnings

⚠ Endometrial Cancer:

Unopposed estrogen increases risk 8-10 fold
Requires progestin co-therapy in non-hysterectomized women

⚠ Cardiovascular Risks:

Lower than oral estrogens but still present

⚠ Dementia Risk: Increased in women >65 years

Contraindications

❌ Active arterial thromboembolism
❌ Estrogen-sensitive malignancies
❌ Severe hepatic impairment

Adverse Effects

Local (≥5%)	Systemic (<5%)
Skin irritation	Breast tenderness
Pruritus	Headache
Erythema	Fluid retention

9. COMPARISON WITH OTHER HRT FORMULATIONS

Parameter	ORGAMED Patch	Oral Estradiol	Vaginal Estrogen
VTE Risk	+	+++	+
Hepatic Impact	Minimal	Significant	Minimal
Dosing Frequency	2x weekly	Daily	2-3x weekly
Libido Effect	Neutral	Neutral	Local benefit

10. PATIENT COUNSELING POINTS

✔ Proper application technique:

Avoid breasts/waistline areas
Remove old patch before applying new

✔ Warning signs requiring medical attention:

Severe skin reactions
New breast lumps
Visual disturbances

✔ Advantages over oral therapy:

Lower stroke risk
No triglyceride elevation
Better for hypertension patients

CONCLUSION

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Brand Name: ORGAMED
Generic Name: Estradiol Hemihydrate
Therapeutic Class: Transdermal Estrogen Therapy
Delivery System: Matrix-type patch (adhesive layer contains active drug)
Available Strengths:
- 25 μg/day (7.6 mg estradiol)
- 50 μg/day (15.2 mg estradiol)
- 75 μg/day (22.8 mg estradiol)
- 100 μg/day (30.4 mg estradiol)

2. COMPOSITION

Component	Function
Estradiol Hemihydrate	Active ingredient
Polyacrylate adhesive	Matrix carrier
Polyester film	Backing layer
Silicone-coated release liner	Protective layer

(Alcohol-free formulation, suitable for sensitive skin)

3. MECHANISM OF ACTION

✔ Continuous transdermal delivery of 17β-estradiol:

Avoids first-pass hepatic metabolism
Maintains stable serum levels (no peaks/troughs)
✔ Therapeutic Effects:
Relieves vasomotor symptoms (hot flashes/night sweats)
Prevents postmenopausal bone loss
Improves urogenital atrophy
May enhance mood/cognitive function

4. DOSAGE & ADMINISTRATION

Standard Regimens

Clinical Scenario	Initial Dose	Maintenance Dose	Patch Change Frequency
Vasomotor Symptoms	25-50 μg/day	Lowest effective dose	Twice weekly
Osteoporosis Prevention	50 μg/day	Long-term	Twice weekly
With Progestin (Intact Uterus)	Add oral/transdermal progestin 12-14 days/month

Application Guide

Site Selection: Clean, dry skin on lower abdomen or buttock
Rotation: Avoid same site for ≥1 week
Adhesion: Press firmly for 10 seconds
Water Resistance: Safe for bathing/swimming

5. INDICATIONS

✅ Moderate-to-severe menopausal symptoms
✅ Prevention of postmenopausal osteoporosis
✅ Hypoestrogenism (surgical/natural menopause)

6. STORAGE CONDITIONS

Unopened Pouches: Below 25°C (do not refrigerate)
After Removal from Pouch: Apply immediately
Shelf Life: 36 months

7. KEY RECOMMENDATIONS

✔ Start therapy within 10 years of menopause for cardiovascular benefit
✔ Annual breast/endometrial monitoring (if uterus present)
✔ Consider lower doses (25 μg) for older women (>65 years)
✔ Patch-free interval not required (continuous dosing)

8. IMPORTANT SAFETY NOTES

Black Box Warnings

⚠ Endometrial Cancer:

Unopposed estrogen increases risk 8-10 fold
Requires progestin co-therapy in non-hysterectomized women

⚠ Cardiovascular Risks:

Lower than oral estrogens but still present

⚠ Dementia Risk: Increased in women >65 years

Contraindications

❌ Active arterial thromboembolism
❌ Estrogen-sensitive malignancies
❌ Severe hepatic impairment

Adverse Effects

Local (≥5%)	Systemic (<5%)
Skin irritation	Breast tenderness
Pruritus	Headache
Erythema	Fluid retention

9. COMPARISON WITH OTHER HRT FORMULATIONS

Parameter	ORGAMED Patch	Oral Estradiol	Vaginal Estrogen
VTE Risk	+	+++	+
Hepatic Impact	Minimal	Significant	Minimal
Dosing Frequency	2x weekly	Daily	2-3x weekly
Libido Effect	Neutral	Neutral	Local benefit

10. PATIENT COUNSELING POINTS

✔ Proper application technique:

Avoid breasts/waistline areas
Remove old patch before applying new

✔ Warning signs requiring medical attention:

Severe skin reactions
New breast lumps
Visual disturbances

✔ Advantages over oral therapy:

Lower stroke risk
No triglyceride elevation
Better for hypertension patients

CONCLUSION

Reviews

There are no reviews yet.

Be the first to review “ORGAMED”

Description
Reviews (0)

Brand Name: ORGAMED
Generic Name: Estradiol Hemihydrate
Therapeutic Class: Transdermal Estrogen Therapy
Delivery System: Matrix-type patch (adhesive layer contains active drug)
Available Strengths:
- 25 μg/day (7.6 mg estradiol)
- 50 μg/day (15.2 mg estradiol)
- 75 μg/day (22.8 mg estradiol)
- 100 μg/day (30.4 mg estradiol)

2. COMPOSITION

Component	Function
Estradiol Hemihydrate	Active ingredient
Polyacrylate adhesive	Matrix carrier
Polyester film	Backing layer
Silicone-coated release liner	Protective layer

(Alcohol-free formulation, suitable for sensitive skin)

3. MECHANISM OF ACTION

✔ Continuous transdermal delivery of 17β-estradiol:

Avoids first-pass hepatic metabolism
Maintains stable serum levels (no peaks/troughs)
✔ Therapeutic Effects:
Relieves vasomotor symptoms (hot flashes/night sweats)
Prevents postmenopausal bone loss
Improves urogenital atrophy
May enhance mood/cognitive function

4. DOSAGE & ADMINISTRATION

Standard Regimens

Clinical Scenario	Initial Dose	Maintenance Dose	Patch Change Frequency
Vasomotor Symptoms	25-50 μg/day	Lowest effective dose	Twice weekly
Osteoporosis Prevention	50 μg/day	Long-term	Twice weekly
With Progestin (Intact Uterus)	Add oral/transdermal progestin 12-14 days/month

Application Guide

Site Selection: Clean, dry skin on lower abdomen or buttock
Rotation: Avoid same site for ≥1 week
Adhesion: Press firmly for 10 seconds
Water Resistance: Safe for bathing/swimming

5. INDICATIONS

✅ Moderate-to-severe menopausal symptoms
✅ Prevention of postmenopausal osteoporosis
✅ Hypoestrogenism (surgical/natural menopause)

6. STORAGE CONDITIONS

Unopened Pouches: Below 25°C (do not refrigerate)
After Removal from Pouch: Apply immediately
Shelf Life: 36 months

7. KEY RECOMMENDATIONS

✔ Start therapy within 10 years of menopause for cardiovascular benefit
✔ Annual breast/endometrial monitoring (if uterus present)
✔ Consider lower doses (25 μg) for older women (>65 years)
✔ Patch-free interval not required (continuous dosing)

8. IMPORTANT SAFETY NOTES

Black Box Warnings

⚠ Endometrial Cancer:

Unopposed estrogen increases risk 8-10 fold
Requires progestin co-therapy in non-hysterectomized women

⚠ Cardiovascular Risks:

Lower than oral estrogens but still present

⚠ Dementia Risk: Increased in women >65 years

Contraindications

❌ Active arterial thromboembolism
❌ Estrogen-sensitive malignancies
❌ Severe hepatic impairment

Adverse Effects

Local (≥5%)	Systemic (<5%)
Skin irritation	Breast tenderness
Pruritus	Headache
Erythema	Fluid retention

9. COMPARISON WITH OTHER HRT FORMULATIONS

Parameter	ORGAMED Patch	Oral Estradiol	Vaginal Estrogen
VTE Risk	+	+++	+
Hepatic Impact	Minimal	Significant	Minimal
Dosing Frequency	2x weekly	Daily	2-3x weekly
Libido Effect	Neutral	Neutral	Local benefit

10. PATIENT COUNSELING POINTS

✔ Proper application technique:

Avoid breasts/waistline areas
Remove old patch before applying new

✔ Warning signs requiring medical attention:

Severe skin reactions
New breast lumps
Visual disturbances

✔ Advantages over oral therapy:

Lower stroke risk
No triglyceride elevation
Better for hypertension patients

CONCLUSION

Reviews

There are no reviews yet.

Be the first to review “ORGAMED”

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