UTEROGESTAN 100 mg is a natural micronized progesterone preparation in soft gelatin capsules for oral or vaginal use. It is widely prescribed for luteal phase support, hormonal imbalances, and menopausal hormone therapy.
Composition
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Active Ingredient: Natural Progesterone 100 mg (micronized for better absorption).
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Vehicle: Peanut oil, soy lecithin, gelatin, glycerin.
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Excipients: Titanium dioxide (for capsule coating).
(Bioidentical to human progesterone – no synthetic progestins.)
Mechanism of Action
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Binds to progesterone receptors in the endometrium, ovaries, and brain.
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Prepares the uterus for implantation (supports the luteal phase in fertility treatments).
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Balances estrogen effects (prevents endometrial hyperplasia in HRT).
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Suppresses uterine contractions (useful in threatened miscarriage).
Dosage & Administration
By Indication
Condition | Dosage | Route | Duration |
---|---|---|---|
Luteal Phase Support (IVF/IUI) | 200–400 mg/day | Vaginal (preferred) | Until 10–12 weeks gestation |
HRT (with Estrogen) | 100–200 mg/day | Oral/Vaginal | 12–14 days/month |
Threatened Miscarriage | 200–400 mg/day | Vaginal | Until symptoms resolve |
Secondary Amenorrhea | 200–300 mg/day | Oral | 10–12 days/month |
Key Notes
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Vaginal route has higher uterine bioavailability (less systemic side effects).
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Oral administration causes drowsiness (take at bedtime).
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With food enhances absorption (oral use).
Indications
✅ Assisted reproduction (IVF/IUI luteal support).
✅ Hormone replacement therapy (HRT) in postmenopausal women.
✅ Menstrual disorders (amenorrhea, heavy bleeding).
✅ Threatened or recurrent miscarriage.
Storage & Stability
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Store below 25°C (protect from light & moisture).
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Do not freeze (soft capsules may rupture).
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Shelf life: 3 years.
Key Recommendations
✔ Vaginal use preferred in fertility treatments (higher endometrial effect).
✔ Monitor for breakthrough bleeding (adjust dose if needed).
✔ Avoid in active thromboembolic disorders (minimal risk vs. synthetic progestins).
Important Safety Notes
âš Â Pregnancy (Category B): Safe in pregnancy for luteal support.
âš Â Breastfeeding: Compatible (low milk transfer).
âš Â Contraindications:
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Undiagnosed vaginal bleeding
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Severe liver disease
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Progesterone-sensitive cancers
âš Â Side Effects:
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Common: Drowsiness (oral), vaginal discharge (vaginal).
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Rare: Allergic reactions (peanut/soy allergy warning).
Comparison with Other Progesterones
Feature | UTEROGESTAN | Medroxyprogesterone | Dydrogesterone |
---|---|---|---|
Type | Natural micronized | Synthetic | Synthetic (retroprogesterone) |
Drowsiness | High (oral) | Minimal | Minimal |
Thrombosis Risk | Low | Moderate | Low |
Fertility Use | Preferred | Not used | Alternative |
Why Choose UTEROGESTAN?
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Bioidentical hormone (no androgenic side effects).
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Flexible administration (oral/vaginal).
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Well-tolerated in long-term HRT.
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