PHYTON is a vitamin K1 (phytonadione) injectable solution used to prevent and treat bleeding disorders caused by vitamin K deficiency. It is essential for blood clotting and is commonly administered in newborns, surgical patients, and individuals with malabsorption issues.
Composition
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Active Ingredient:
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Phytonadione (Vitamin K1) – 1 mg/mL or 10 mg/mL (strength varies).
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Inactive Ingredients:
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Polyoxyethylated fatty acid derivatives, dextrose, or other stabilizers (varies by brand).
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Mechanism of Action
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Stimulates production of clotting factors (II, VII, IX, X) in the liver.
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Reverses anticoagulant effects (e.g., warfarin toxicity).
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Prevents hemorrhagic disease in newborns (who have low vitamin K stores).
Dosage & Administration
1. For Newborns (Prophylaxis):
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0.5–1 mg IM (single dose at birth).
2. For Vitamin K Deficiency Bleeding:
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2.5–10 mg IM/IV/Subcutaneously (dose depends on severity).
3. For Warfarin Overdose:
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2.5–10 mg IV (slow infusion) + fresh frozen plasma (FFP) if severe.
Administration Notes:
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IV use: Must be given slowly (risk of anaphylactoid reactions).
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IM/Subcutaneous: Preferred for prophylaxis.
Uses
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Newborn Hemorrhagic Disease Prevention.
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Anticoagulant Reversal (warfarin toxicity).
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Malabsorption Syndromes (e.g., biliary obstruction, cystic fibrosis).
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Pre-Surgical Preparation (in patients with prolonged PT/INR).
Storage
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Protect from light (store in original packaging).
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Refrigerate (2–8°C) – Some formulations may require cooling.
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Do not freeze.
Recommendations
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Monitor PT/INRÂ after administration (especially in warfarin reversal).
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Newborns: Routine IM injection is standard in many countries.
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IV use: Reserve for emergencies (higher risk of reactions).
Important Notes
Side Effects
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Rare but serious: Anaphylaxis (especially with IV use).
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Mild: Flushing, taste changes, injection site pain.
Contraindications
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Hypersensitivity to phytonadione or formulation components.
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Severe liver disease (may not respond to vitamin K).
Pregnancy & Breastfeeding
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Safe in pregnancy & lactation (no known fetal risks).
Always administer under medical supervision—rapid IV infusion can be dangerous.
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