FOLICULIN 150 is a recombinant FSH (rFSH) injection used in fertility treatments to stimulate ovarian follicle development in women and sperm production in men with hypogonadotropic hypogonadism.
Composition
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Active Ingredient:Â Follitropin alfa/beta 150 IUÂ (recombinant human FSH).
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Form: Lyophilized powder or prefilled pen (with solvent for reconstitution).
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Purity: Highly purified (no LH activity, minimal proteins).
Mechanism of Action
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Directly stimulates ovarian follicles (in women).
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Supports spermatogenesis (in men with low FSH).
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Used in ART (IVF/IUI) & ovulation induction.
Dosage & Administration
For Women
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Ovulation Induction (OI): 75–150 IU/day SC/IM (adjust per response).
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IVF/ICSI: 150–450 IU/day (based on ovarian reserve).
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Duration: 7–14 days (until follicles reach 17–20 mm).
For Men
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150–300 IU 2–3x/week (with hCG) for spermatogenesis.
Reconstitution
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Mix powder with provided solvent.
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Inject subcutaneously (preferred) or IM.
Indications
✅ Anovulation (PCOS, hypothalamic origin).
✅ Assisted Reproductive Technology (IVF/IUI).
✅ Male infertility (hypogonadotropic hypogonadism).
Storage & Stability
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Unopened vials/pens: 2–8°C (do not freeze).
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After reconstitution: Use immediately (discard unused portions).
Key Recommendations
✔ Monitor with ultrasound & estradiol levels (prevent OHSS).
✔ Start low in PCOS (high OHSS risk).
✔ Rotate injection sites (avoid lipoatrophy).
Important Safety Notes
⚠ Ovarian Hyperstimulation Syndrome (OHSS) Risk – Requires close monitoring.
⚠ Multiple Pregnancy Risk – Higher with fertility drugs.
âš Â Contraindications:
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Ovarian/testicular tumors
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Pregnancy
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Uncontrolled thyroid disease
Comparison with Other FSH Preparations
Feature | FOLICULIN 150 (rFSH) | hMG (Menopur) | Clomiphene Citrate |
---|---|---|---|
Hormone | Pure FSH | FSH + LH | Oral anti-estrogen |
Purity | Recombinant (no LH) | Urinary-derived | N/A |
Male Use | Yes | Yes | No |
Cost | High | Moderate | Low |
Conclusion
FOLICULIN 150 is a high-purity rFSH for ovulation induction & ART, offering better consistency than urinary FSH.
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