HUMOG 150 is a highly purified human menopausal gonadotropin (hMG) injection containing both FSH (Follicle-Stimulating Hormone) and LH (Luteinizing Hormone) activity. It is used for ovulation induction in women and spermatogenesis stimulation in men with hypogonadotropic hypogonadism.
Composition
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Active Ingredients:
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FSH 75 IUÂ +Â LH 75 IUÂ per ampoule (1:1 ratio).
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Source:Â Urinary-derived, highly purified (reduced protein content).
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Form: Lyophilized powder with solvent for reconstitution.
Mechanism of Action
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FSH: Stimulates follicular growth in ovaries.
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LH: Supports estrogen production and final oocyte maturation.
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Used in combination with hCGÂ to trigger ovulation.
Dosage & Administration
For Women (Ovulation Induction)
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Starting dose: 75–150 IU/day (IM/SC injection).
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Adjust based on response (ultrasound & estrogen monitoring).
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Duration: 7–14 days (until follicles reach 17–20 mm).
For Men (Hypogonadotropic Hypogonadism)
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150 IU 2–3 times/week (with hCG) for spermatogenesis.
Reconstitution & Injection
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Reconstitute powder with provided solvent.
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Administer IM or SCÂ (rotate injection sites).
Indications
✅ Anovulatory infertility (e.g., PCOS, hypothalamic dysfunction).
✅ Assisted Reproductive Technology (ART/IVF).
✅ Male infertility (low FSH/LH).
Storage & Stability
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Unreconstituted: Store at 2–8°C (refrigerate).
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After mixing: Use immediately (discard unused portions).
Key Recommendations
✔ Monitor with ultrasound & estradiol levels (prevent OHSS).
✔ Start at lower doses in PCOS (high OHSS risk).
✔ Use under specialist supervision.
Important Safety Notes
⚠ Ovarian Hyperstimulation Syndrome (OHSS) Risk – Requires close monitoring.
⚠ Multiple Pregnancy Risk – Higher with fertility treatments.
âš Â Contraindications:
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Ovarian/testicular tumors
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Pregnancy
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Uncontrolled thyroid/adrenal disorders
Comparison with Other Gonadotropins
Feature | HUMOG 150 (hMG) | Recombinant FSH (Gonal-F) | Clomiphene Citrate |
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Hormones | FSH + LH | Pure FSH | Oral anti-estrogen |
Purity | Highly purified | Ultra-pure | N/A |
Use in Men | Yes | No | No |
OHSS Risk | Moderate | Moderate | Low |
Conclusion
HUMOG 150 is a versatile gonadotropin for ovulation induction & male infertility, offering both FSH and LH activity for balanced stimulation.
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