PRIMIGYN

Women Health

Description
Shipping Options
Customer Reviews

Generic Name: Letrozole
Therapeutic Class: Aromatase inhibitor (3rd generation)
Available Forms: 2.5 mg film-coated tablets
Manufacturer: Various (generic versions available)

2. Composition

Active Ingredient: Letrozole 2.5 mg
Excipients:
- Lactose monohydrate
- Microcrystalline cellulose
- Sodium starch glycolate
- Hypromellose
- Magnesium stearate

3. Mechanism of Action

Reversible inhibition of aromatase enzyme
Blocks conversion of androgens to estrogens
Results in:
- Reduced estrogen levels (serum E2 <20 pg/mL)
- Increased FSH secretion from pituitary
- Enhanced follicular recruitment

4. Dosage & Administration

For Fertility Treatment

Protocol	Dose	Duration	Monitoring
Ovulation Induction	2.5-5 mg/day	Days 3-7 of cycle	Follicular tracking
IVF Stimulation	5 mg/day	Days 3-7	E2 levels + ultrasound
Poor Responders	5-7.5 mg/day	Extended protocols	Intensive monitoring

For Breast Cancer

2.5 mg once daily (continuous)
Duration: Until disease progression

Administration Notes

Take with or without food
Best taken in morning
For fertility: precise cycle day initiation critical

5. Indications

✔ First-line ovulation induction (PCOS patients) ✔ Adjuvant therapy for hormone-receptor positive breast cancer ✔ Extended adjuvant therapy post-tamoxifen ✔ Male infertility (off-label for testosterone enhancement)

6. Storage Conditions

Temperature: Below 30°C
Humidity: Keep in original packaging
Shelf Life: Typically 36 months
Protection: Avoid moisture and light

7. Key Recommendations

For Fertility:
- Start ultrasound monitoring on day 10
- Consider hCG trigger when lead follicle reaches 18mm
- Limit to 6 treatment cycles
For Oncology:
- Monitor bone mineral density annually
- Assess lipid profile regularly
- Manage arthralgia with NSAIDs

8. Important Safety Information

Warnings

⚠ Fetal toxicity (Pregnancy Category X) ⚠ Decreased bone mineral density ⚠ Increased cholesterol levels

Contraindications

❌ Pregnancy ❌ Premenopausal women without ovarian suppression ❌ Severe hepatic impairment

Adverse Effects

Common:
- Hot flashes (20%)
- Fatigue (15%)
- Arthralgia (12%)
Serious:
- Osteoporosis (long-term use)
- Cardiovascular events
- Depression

9. Comparison with Other Fertility Agents

Parameter	PRIMIGYN	Clomiphene	Gonadotropins
Pregnancy Rate	25-30%	15-20%	20-25%
Multiple Pregnancy	3-5%	5-8%	15-30%
Cycle Control	Good	Moderate	Requires intensive monitoring
Cost per Cycle	$	$	$$$

10. Patient Counseling Points

For fertility patients:
- Use barrier contraception during treatment
- Report severe pelvic pain immediately
- Understand timing for intercourse/IUI
For cancer patients:
- Importance of calcium/vitamin D supplementation
- Regular exercise for bone health
- Management of menopausal symptoms

11. Regulatory Status

FDA Approved:
- Breast cancer (1997)
- Off-label for fertility
Pregnancy Category: X
Prescription Requirements: Mandatory

Generic Name: Letrozole
Therapeutic Class: Aromatase inhibitor (3rd generation)
Available Forms: 2.5 mg film-coated tablets
Manufacturer: Various (generic versions available)

2. Composition

Active Ingredient: Letrozole 2.5 mg
Excipients:
- Lactose monohydrate
- Microcrystalline cellulose
- Sodium starch glycolate
- Hypromellose
- Magnesium stearate

3. Mechanism of Action

Reversible inhibition of aromatase enzyme
Blocks conversion of androgens to estrogens
Results in:
- Reduced estrogen levels (serum E2 <20 pg/mL)
- Increased FSH secretion from pituitary
- Enhanced follicular recruitment

4. Dosage & Administration

For Fertility Treatment

Protocol	Dose	Duration	Monitoring
Ovulation Induction	2.5-5 mg/day	Days 3-7 of cycle	Follicular tracking
IVF Stimulation	5 mg/day	Days 3-7	E2 levels + ultrasound
Poor Responders	5-7.5 mg/day	Extended protocols	Intensive monitoring

For Breast Cancer

2.5 mg once daily (continuous)
Duration: Until disease progression

Administration Notes

Take with or without food
Best taken in morning
For fertility: precise cycle day initiation critical

5. Indications

✔ First-line ovulation induction (PCOS patients)
✔ Adjuvant therapy for hormone-receptor positive breast cancer
✔ Extended adjuvant therapy post-tamoxifen
✔ Male infertility (off-label for testosterone enhancement)

6. Storage Conditions

Temperature: Below 30°C
Humidity: Keep in original packaging
Shelf Life: Typically 36 months
Protection: Avoid moisture and light

7. Key Recommendations

For Fertility:
- Start ultrasound monitoring on day 10
- Consider hCG trigger when lead follicle reaches 18mm
- Limit to 6 treatment cycles
For Oncology:
- Monitor bone mineral density annually
- Assess lipid profile regularly
- Manage arthralgia with NSAIDs

8. Important Safety Information

Warnings

⚠ Fetal toxicity (Pregnancy Category X)
⚠ Decreased bone mineral density
⚠ Increased cholesterol levels

Contraindications

❌ Pregnancy
❌ Premenopausal women without ovarian suppression
❌ Severe hepatic impairment

Adverse Effects

Common:
- Hot flashes (20%)
- Fatigue (15%)
- Arthralgia (12%)
Serious:
- Osteoporosis (long-term use)
- Cardiovascular events
- Depression

9. Comparison with Other Fertility Agents

Parameter	PRIMIGYN	Clomiphene	Gonadotropins
Pregnancy Rate	25-30%	15-20%	20-25%
Multiple Pregnancy	3-5%	5-8%	15-30%
Cycle Control	Good	Moderate	Requires intensive monitoring
Cost per Cycle	$	$	$$$

10. Patient Counseling Points

For fertility patients:
- Use barrier contraception during treatment
- Report severe pelvic pain immediately
- Understand timing for intercourse/IUI
For cancer patients:
- Importance of calcium/vitamin D supplementation
- Regular exercise for bone health
- Management of menopausal symptoms

11. Regulatory Status

FDA Approved:
- Breast cancer (1997)
- Off-label for fertility
Pregnancy Category: X
Prescription Requirements: Mandatory

Shipping Options –

We offer a variety of shipping options, including Express Mail Service (EMS), USPS, DHL, FedEx, TNT, UPS, Aramex, Air Cargo, and sea freight.

Terms and Conditions –

Bulk Orders: You are responsible for any local import duties and taxes in your country.

For Patients: When ordering prescription medicines for personal use, or for a friend or relative, a valid medical practitioner’s script or prescription is required.

Return and Refund Policy: Due to the nature of our products, we cannot accept returns or exchanges once a purchase is made. However, in the event of non-delivery, you are eligible for either a 100% refund or a reshipment of your order.

Description
Reviews (0)

Generic Name: Letrozole
Therapeutic Class: Aromatase inhibitor (3rd generation)
Available Forms: 2.5 mg film-coated tablets
Manufacturer: Various (generic versions available)

2. Composition

Active Ingredient: Letrozole 2.5 mg
Excipients:
- Lactose monohydrate
- Microcrystalline cellulose
- Sodium starch glycolate
- Hypromellose
- Magnesium stearate

3. Mechanism of Action

Reversible inhibition of aromatase enzyme
Blocks conversion of androgens to estrogens
Results in:
- Reduced estrogen levels (serum E2 <20 pg/mL)
- Increased FSH secretion from pituitary
- Enhanced follicular recruitment

4. Dosage & Administration

For Fertility Treatment

Protocol	Dose	Duration	Monitoring
Ovulation Induction	2.5-5 mg/day	Days 3-7 of cycle	Follicular tracking
IVF Stimulation	5 mg/day	Days 3-7	E2 levels + ultrasound
Poor Responders	5-7.5 mg/day	Extended protocols	Intensive monitoring

For Breast Cancer

2.5 mg once daily (continuous)
Duration: Until disease progression

Administration Notes

Take with or without food
Best taken in morning
For fertility: precise cycle day initiation critical

5. Indications

✔ First-line ovulation induction (PCOS patients)
✔ Adjuvant therapy for hormone-receptor positive breast cancer
✔ Extended adjuvant therapy post-tamoxifen
✔ Male infertility (off-label for testosterone enhancement)

6. Storage Conditions

Temperature: Below 30°C
Humidity: Keep in original packaging
Shelf Life: Typically 36 months
Protection: Avoid moisture and light

7. Key Recommendations

For Fertility:
- Start ultrasound monitoring on day 10
- Consider hCG trigger when lead follicle reaches 18mm
- Limit to 6 treatment cycles
For Oncology:
- Monitor bone mineral density annually
- Assess lipid profile regularly
- Manage arthralgia with NSAIDs

8. Important Safety Information

Warnings

⚠ Fetal toxicity (Pregnancy Category X)
⚠ Decreased bone mineral density
⚠ Increased cholesterol levels

Contraindications

❌ Pregnancy
❌ Premenopausal women without ovarian suppression
❌ Severe hepatic impairment

Adverse Effects

Common:
- Hot flashes (20%)
- Fatigue (15%)
- Arthralgia (12%)
Serious:
- Osteoporosis (long-term use)
- Cardiovascular events
- Depression

9. Comparison with Other Fertility Agents

Parameter	PRIMIGYN	Clomiphene	Gonadotropins
Pregnancy Rate	25-30%	15-20%	20-25%
Multiple Pregnancy	3-5%	5-8%	15-30%
Cycle Control	Good	Moderate	Requires intensive monitoring
Cost per Cycle	$	$	$$$

10. Patient Counseling Points

For fertility patients:
- Use barrier contraception during treatment
- Report severe pelvic pain immediately
- Understand timing for intercourse/IUI
For cancer patients:
- Importance of calcium/vitamin D supplementation
- Regular exercise for bone health
- Management of menopausal symptoms

11. Regulatory Status

FDA Approved:
- Breast cancer (1997)
- Off-label for fertility
Pregnancy Category: X
Prescription Requirements: Mandatory

Reviews

There are no reviews yet.

Be the first to review “PRIMIGYN”

Description
Reviews (0)

Generic Name: Letrozole
Therapeutic Class: Aromatase inhibitor (3rd generation)
Available Forms: 2.5 mg film-coated tablets
Manufacturer: Various (generic versions available)

2. Composition

Active Ingredient: Letrozole 2.5 mg
Excipients:
- Lactose monohydrate
- Microcrystalline cellulose
- Sodium starch glycolate
- Hypromellose
- Magnesium stearate

3. Mechanism of Action

Reversible inhibition of aromatase enzyme
Blocks conversion of androgens to estrogens
Results in:
- Reduced estrogen levels (serum E2 <20 pg/mL)
- Increased FSH secretion from pituitary
- Enhanced follicular recruitment

4. Dosage & Administration

For Fertility Treatment

Protocol	Dose	Duration	Monitoring
Ovulation Induction	2.5-5 mg/day	Days 3-7 of cycle	Follicular tracking
IVF Stimulation	5 mg/day	Days 3-7	E2 levels + ultrasound
Poor Responders	5-7.5 mg/day	Extended protocols	Intensive monitoring

For Breast Cancer

2.5 mg once daily (continuous)
Duration: Until disease progression

Administration Notes

Take with or without food
Best taken in morning
For fertility: precise cycle day initiation critical

5. Indications

✔ First-line ovulation induction (PCOS patients)
✔ Adjuvant therapy for hormone-receptor positive breast cancer
✔ Extended adjuvant therapy post-tamoxifen
✔ Male infertility (off-label for testosterone enhancement)

6. Storage Conditions

Temperature: Below 30°C
Humidity: Keep in original packaging
Shelf Life: Typically 36 months
Protection: Avoid moisture and light

7. Key Recommendations

For Fertility:
- Start ultrasound monitoring on day 10
- Consider hCG trigger when lead follicle reaches 18mm
- Limit to 6 treatment cycles
For Oncology:
- Monitor bone mineral density annually
- Assess lipid profile regularly
- Manage arthralgia with NSAIDs

8. Important Safety Information

Warnings

⚠ Fetal toxicity (Pregnancy Category X)
⚠ Decreased bone mineral density
⚠ Increased cholesterol levels

Contraindications

❌ Pregnancy
❌ Premenopausal women without ovarian suppression
❌ Severe hepatic impairment

Adverse Effects

Common:
- Hot flashes (20%)
- Fatigue (15%)
- Arthralgia (12%)
Serious:
- Osteoporosis (long-term use)
- Cardiovascular events
- Depression

9. Comparison with Other Fertility Agents

Parameter	PRIMIGYN	Clomiphene	Gonadotropins
Pregnancy Rate	25-30%	15-20%	20-25%
Multiple Pregnancy	3-5%	5-8%	15-30%
Cycle Control	Good	Moderate	Requires intensive monitoring
Cost per Cycle	$	$	$$$

10. Patient Counseling Points

For fertility patients:
- Use barrier contraception during treatment
- Report severe pelvic pain immediately
- Understand timing for intercourse/IUI
For cancer patients:
- Importance of calcium/vitamin D supplementation
- Regular exercise for bone health
- Management of menopausal symptoms

11. Regulatory Status

FDA Approved:
- Breast cancer (1997)
- Off-label for fertility
Pregnancy Category: X
Prescription Requirements: Mandatory

Reviews

There are no reviews yet.

Be the first to review “PRIMIGYN”

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