Introduction
ENTAVIR 1mg is a higher-dose formulation of Entecavir, a potent nucleoside analogue antiviral used for chronic hepatitis B (HBV) infection. It is specifically prescribed for:
-
Lamivudine-resistant HBV patients
-
HIV-coinfected HBV patients (who are not on HIV treatment)
Generic Name: Entecavir
Brand Equivalents: Baraclude (original), Entavir, Clevudine (in some regions)
Available Form:
-
Tablets: 1 mg (white, film-coated)
-
Oral Solution: 0.05 mg/mL
Uses of ENTAVIR 1mg
✔ Chronic Hepatitis B (HBV) with prior lamivudine resistance
✔ HBV patients with HIV co-infection (not on ART)
✔ Compensated liver disease (cirrhosis, if stable)
Not for:
❌ Acute hepatitis B
❌ Hepatitis C (HCV) or other viruses
❌ HIV treatment (only for HBV suppression)
Dosage & Administration
-
Standard Dose: 1 mg once daily (for lamivudine-resistant or HIV-coinfected patients)
-
Empty Stomach: Take at least 2 hours before or after meals for best absorption.
-
Missed Dose: Take as soon as remembered, but skip if close to next dose.
-
Do NOT stop abruptly → Risk of severe HBV flare-up!
Side Effects
Common (Usually Mild):
-
Headache, dizziness
-
Fatigue
-
Mild nausea, diarrhea
Serious (Seek Medical Help):
-
Lactic acidosis (muscle pain, rapid breathing, weakness)
-
Liver toxicity (yellow skin, dark urine, confusion)
-
Kidney impairment (swelling, reduced urine output)
Storage Instructions
-
Room temperature (15–30°C)
-
Keep away from moisture & light
-
Do not freeze (for oral solution)
-
Keep out of children’s reach
Why ENTAVIR 1mg is Important?
-
Strong HBV Suppression – Very low resistance risk compared to older drugs.
-
Rescue Therapy – Effective for lamivudine-resistant HBV cases.
-
Long-Term Safety – Preferred for years of treatment with fewer side effects.
-
Prevents Liver Damage – Reduces cirrhosis & liver cancer risk.
Precautions & Warnings
⚠ HBV Flare Risk – Stopping suddenly can cause life-threatening hepatitis.
⚠ Kidney Monitoring Needed – Especially in elderly or dehydrated patients.
⚠ Not a Cure – Controls HBV but rarely eliminates it.
⚠ Pregnancy & Breastfeeding – Use only if benefits outweigh risks.
Drug Interactions
-
HIV medications (e.g., Tenofovir) → May need dose adjustments.
-
Nephrotoxic drugs (NSAIDs, aminoglycosides) → Increased kidney risk
Reviews
There are no reviews yet.